Serotonin (5-HT) neurotransmission in the brain relies on a widespread axon terminal network originating from the hindbrain raphe nuclei. These projections are topographically organized such that the dorsal (DR), and median raphe (MnR) nuclei have different brain targets. However, the guidance molecules involved in this selective targeting in development are unknown. Here, we show the implicati...

So what’s the fuss? In mammals, it is the site of an endogenous pacemaker that regulates 24 hour, circadian rhythmicity, synchronizing the phases and periods of a host of behavioral, physiological, and hormonal rhythms to the environmental light–dark cycle. The SCN also appears to function as a seasonal clock underlying the measurement of daylength. The SCN was first implicated as a master cloc...

Abstract Introduction Recurrent arousals in obstructive sleep apnea (OSA) may lead to alteration functional connection involving the ascending reticular activating system (ARAS). We aimed evaluate resting-state connectivity (FC) between eight ARAS nuclei and 105 cortical/subcortical regions OSA patients matched controls. Methods Total of 50 with moderate severe 20 controls without underwent ove...

introduction: the septal region is part of the telencephalon and is a component of the limbic system. the lateral septal area (ls); largest nuclear mass in this region, plays a pivotal role in various physiological processes, such as aggression, emotion, thermoregulation, water and food intake and sexual behaviour. to support the functional analysis of this brain area in the rat, the sources of...

The present study provides the first autoradiographic evidence of age-dependent regional changes in the density of serotonin (5-HT) transporters in offspring following prenatal exposure to fluoxetine. Pregnant rats received either saline or fluoxetine (10 mg/kg, s.c.) daily from gestational day 13 through 20. The density of [3H]citalopram-labeled 5-HT transporters was determined in forebrain re...

3,4-Methylenedioxymethamphetamine (MDMA, 'ecstasy') is a recreational drug widely used by adolescents and young adults. Although its rewarding effects are well established, there is controversy on its addictive potential. We aimed to compare the consequences of active and passive MDMA administration on gene expression in the mouse brain since all previous studies were based on passive MDMA admi...