The interaction between smoking and the effect of histamine H2-antagonists on intragastric acidity was examined in a double blind double dummy placebo controlled study. Healthy volunteers, 11 smokers and 10 non-smokers, were given, on four separate days at least one week apart, either placebo or cimetidine 800 mg nocte or ranitidine 2 X 150 mg per day or ranitidine 300 mg nocte. Tablets were ta...

The effects of preoperative oral administration of 150 ml fluid were studied prospectively in 140 unpremedicated, ambulatory outpatients presenting for first trimester therapeutic abortion. Intraoperative gastric fluid volume, pH, and rate of gastric emptying were measured in the four groups to which patients were randomly assigned. At an average time of 2 1/2 hr preoperatively all patients rec...

Background—The eVect of histamine H2 receptor antagonists on gastric emptying is controversial. Aims—To determine the eVects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. Patients and methods—Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (EGG), and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minute...

Two separate studies of 24 hour intragastric acidity were carried out in normal volunteers and duodenal ulcer patients to define the interaction of food and the antisecretory effects of H2-receptor blockers. Both investigations were double blind randomised comparisons using ranitidine 300 mg with either different meal times or ad libitum snacks after an evening meal. Meals taken after drug admi...

BACKGROUND Mycophenolate mofetil (MMF) is the prodrug of mycophenolic acid (MPA). Proton pump inhibitors impair exposure to MPA due to incomplete conversion from MMF. Lower exposure to MPA could result in an increased risk of acute rejection. We investigated whether MMF-treated renal transplant patients who concomitantly used pantoprazole as ulcer prophylaxis had a higher risk of acute rejectio...

BACKGROUND Histamine is responsible for the wheal and flare reaction in various allergic conditions. Classical antihistamines are the drugs which block the H 1 receptors and are widely used in various allergic conditions, whereas H 2 blockers are mainly used for acid peptic disease. Although H 1 receptor-mediated actions of histamine are primarily responsible for vasodilatation, vasopermeabilit...

In the paper " The comparative study of the effectiveness of Cimetidine, Ranitidine, Famotidine, and Omeprazole in treatment of children with dyspepsia " by S. M. Dehghani et al., published in ISRN Pediatrics, Volume 2011, Article ID 219287, one sentence needs to be amended as it is incorrect or incomplete. In the abstract, in line 9, the correct sentence should read " 21.6% for Cimetidine, 43....

This paper gives a new integrable hierarchy of nonlinear evolution equations. In this hierarchy there are the following representative equations: ut = ∂ 5 xu − 2 3 , ut = ∂ 5 x (u 1 3 )xx − 2(u 1 6 )x u ; uxxt + 3uxxux + uxxxu = 0. The first two are in the positive order hierarchy while the 3rd one is in the negative order hierarchy. The whole hierarchy is shown integrable through solving a key...