The aim of the present research was to study the effects of weak cation exchange resins, polacrilex with exchangeable H+ and polacrillin potassium and strong cation exchange resin sodium polystyrene sulfonate on water uptake behavior of ranitidine hydrochloride. Drug resin complexes (DRC) were prepared and evaluated for the percentage of moisture gain when placed in a humidity c...

N-Nitrosodimethylamine (NDMA) is a probable human carcinogen. This study investigated the root cause of presence NDMA in ranitidine hydrochloride. Forced thermal degradation studies hydrochloride and its inherent impurities (Imps. A, B, C, D, E, F, G, H, I, J, K) listed European United States Pharmacopeias revealed that addition to ranitidine, Imps. I produce at different rates solid or an oily...

possible benefit of hypnotherapy in relapse prevention. After the ulcer had healed on treatment with ranitidine, the drug was continued for a further 10 weeks during which time patients received either hypnotherapy or no hypnotherapy. The two randomly selected groups were comparable in terms of age, sex, smoking habits, and alcohol consumption. Follow-up of both groups of patients was continued...

Retrospective analysis of 119 endoscopically proven cases of duodenal ulcer, treated with Famotidin (40 mg),Cimetidine (800 mg) and Ranitidine (300 mg) at bed -time, showed heating rates of 91, 74 and 68%, respectively, at 6 weeks. Twenty patients were followed up for one year on maintenance dose and endoscoped at 3, 6 and 12 months. Despite taking the drug regularly a relapse rate of 14% was s...

stool samples and rectal biopsy showed a moderately active non-specific proctitis. Two weeks after his admission discrete ulceration and a thickened polypoid mucosa were evident in the descending and distal transverse colon at a limited colonoscopy. The appearances were thought to favour Crohn's disease and the histology was equivocal. He was treated with corticosteroids and was discharged feel...

Crocin is a plant-derived carotenoid and bears potent antioxidant property. Ranitidine (a histamine H2 receptor blocker) is used for peptic ulcer treatment. The present study was planned to investigate the effects of crocin and ranitidine on indomethacin-induced ulcer in small intestine of rats. Animals were randomized into two major groups including indo-methacin (10.00 mg kg-1...

background nosocomial infections increase mortality rate in neonates. studies have attributed the use of h2 blockers as one of the various factors that increase the risk of nosocomial infections. objectives to define the relationship between nosocomial infection and ranitidine in very low birth weight (vlbw) infants admitted in the nicu of a tertiary care hospital. patients and methods all vlbw...

Background: Previous investigations have revealed, cimetidine, a histamine H2-receptor antagonist, show radioprotective effects against gamma- and neutron-induced micronuclei in bone marrow erythrocytes. In this study, the anticlastogenic effects of famotidine and ranitidine, which act similar to cimetidine as histamine H2-receptor antagonists, was investigated. Materials and Methods : Balb/c m...

Few drugs have so rapidly gained an established place in modern medicine as the histamine H, receptor antagonists. As a result of the inventiveness of James Black and his colleagues, the theoretical concept of a second class of histamine receptors became a therapeutic reality. The failure of classic antihistamine drugs (more appropriately H1 receptor antagonists) to block the actions of histami...