OBJECTIVE To examine the evidence for efficacy of surgery in the treatment of intractable epilepsy. METHOD Meta-analysis of randomized clinical trials. RESULTS One randomized clinical trial (n=80) and 3 observational studies are available. INTERPRETATION Compared to medical treatment, the surgery increases the proportion of patients who were free of seizure impairing awareness at 1 year (...

Effect of probiotics supplementation combined with WeChat platform health management on nutritional status, inflammatory factors, and quality life in patients mild-to-moderate ulcerative colitis: a randomized trial

BACKGROUND Failure of the pancreatic remnant anastomosis to heal following pancreato-duodenectomy is a major cause of significant and life-threatening complications, notably a post-operative pancreatic fistula. Recently, non-randomized trials have shown superiority of a most intuitive anastomosis (Blumgart technique), which involves both a duct-to-mucosa and a full-thickness pancreatic "U" stit...

BACKGROUND Evidence suggests that cluster randomized trials are often poorly designed and analysed. There is little recent research on the methodologic quality of cluster randomized trials and none focuses on primary health care where these trials are increasingly common. METHODS We conducted a systematic review of recent cluster randomized trials in primary health care, searching the Cochran...

Objectives: Because only one head-to-head randomized trial of biologics for moderate-to-severe UC has been performed, indirect treatment comparisons remain important. This systematic review and net...

An experiment was conducted during the season from March 2018 – June at Horticulture farm of Lovely Professional University, Phagwara (Punjab). The three replications experimental trial used a randomized block design. Eleven alternative approaches were in trial. Based on findings trial, it possible to concluded that treatment T8 GA3 (100ppm) had significant impact growth and phenological parame...

BACKGROUND Collaborative care is an effective intervention for depression which includes both organizational and patient-level intervention components. The effect in the UK is unknown, as is whether cluster- or patient-randomization would be the most appropriate design for a Phase III clinical trial. METHOD We undertook a Phase II patient-level randomized controlled trial in primary care, nes...