BACKGROUND In previous work, we described viscosity and permittivity microelectromechanical systems (MEMS) sensors for continuous glucose monitoring (CGM) using poly[acrylamide-ran-3-acrylamidophenylboronic acid (PAA-ran-PAAPBA). In order to enhance our MEMS device antifouling properties, a novel, more hydrophilic polymer-sensing fluid was developed. METHOD To optimize sensing performance, we...

Fibrinolytic activity has been reported to be decreased in atherosclerosis. Recently, annexin II was identified as a coreceptor on endothelial cells for plasminogen and tissue plasminogen activator. In this study, we examined whether recombinant annexin II (rAN II) protein can modulate fibrinolytic activity on vascular endothelium in vitro and in vivo. The effect of rAN II on human umbilical ve...

Over the last two decades, the small GTPase Ran has emerged as a central regulator of both mitosis and meiosis, particularly in the generation, maintenance, and regulation of the microtubule (MT)-based bipolar spindle. Ran-regulated pathways in mitosis bear many similarities to the well-characterized functions of Ran in nuclear transport and, as with transport, the majority of these mitotic eff...

Three factors have been identified that reconstitute nuclear protein import in a permeabilized cell assay: the NLS receptor, p97, and Ran/TC4. Ran/ TC4, in turn, interacts with a number of proteins that are involved in the regulation of GTP hydrolysis or are components of the nuclear pore. Two Ran-binding proteins, RanBP1 and RanBP2, form discrete complexes with p97 as demonstrated by immunoads...

We investigate the question “To what extent can random reals be used as a tool to establish number theoretic facts?” Let 2-RAN be the principle that for every real X there is a real R which is 2-random relative to X . In Section 2, we observe that the arguments of Csima and Mileti [3] can be implemented in the base theory RCA0 and so RCA0 +2-RAN implies the Rainbow Ramsey Theorem. In Section 3,...

The Rapid Automatized Naming test (RAN) has been shown to be a strong predictor of reading ability (Bowers and Wolf, 1993), however, the nature of this relationship remains unclear. The purpose of this study was to evaluate whether the visual scanning and sequential components of the continuous RAN format are similar to those same visual scanning processes required in reading, and whether these...

Deregulated cell division is a hallmark of cancer, but whether tumor cells become dependent on specific mitotic mechanisms is not known. Here, we show that the small GTPase Ran, a regulator of mitotic spindle formation, is differentially overexpressed in human cancer as compared with normal tissues, in vivo. Acute silencing of Ran in various tumor cell types causes aberrant mitotic spindle form...

OBJECTIVE It is well known that individuals with anorexia nervosa (AN) are inhibited and over-controlled. This study investigated a prefrontal-cingulate network that is involved in inhibitory control. METHOD To avoid the confounds of malnutrition, 12 recovered (RAN) subjects were compared to 12 matched control women (CW) using a validated inhibition task (i.e., a stop signal task) during func...

Nuclear import of classical nuclear localization sequence-containing proteins involves the assembly of an import complex at the cytoplasmic face of the nuclear pore complex (NPC) followed by movement of this complex through the NPC and release of the import substrate into the nuclear interior. This process has historically been thought to require nucleotide hydrolysis as a source of energy. We ...

The kinetics of phase separation and crystallization in the blends of poly(ethylene-ran-hexene) (PEH) and poly(ethylene-ran-octene) (PEOC) at several compositions were studied using phase contrast optical microscopy and time-resolved simultaneous small-angle X-ray scattering and wide-angle X-ray diffraction. The phase contrast optical microscopy showed the interconnected bicontinuous structure ...