BACKGROUND Patients with lung cancer with mutations in EGF receptor (EGFR) tyrosine kinase have improved prognosis when treated with EGFR inhibitors. We hypothesized that EGFR mutations may be related to residential radon or passive tobacco smoke. METHODS This hypothesis was investigated by analyzing EGFR mutations in 70 lung tumors from a population of never and long-term former female smoke...

Exposure to radon over time has significant detrimental effects on human health. Approximately 226,000 annual radon-related deaths have been reported from 66 countries (1). Many a action plan, in order reduce the harmful of exposure general public. Maps are routinely used assist with mitigation strategies and delineate areas priority regulation. Standard regulations European Union include requi...

Investigations of natural radioactivity in water, air, and soil are conducted frequently and routinely. Exposure to high concentrations of natural radioactive radon gas can cause irradiation of respiratory organs, which can lead to lung cancer. This paper presents measurements of radon activity concentrations in dug wells and natural springs of the Tuzla area (Bosnia and Herzegovina), which ran...

Can a significant number of radon-related lung cancers be averted by mitigating existing single-family houses whose radon is above the action level? Would societal resources be used cost effectively by a comprehensive measurement and mitigation policy using the existing or some other radon action level? Simple questions, complex answers. The risk of lung cancer depends on the radon exposure in ...

The paper presents the results of radon concentration measurements in thermal waters of Kuzuluk and Taraklı (Sakarya, Turkey) and their contribution to annual effective dose exposure. The radon measurements were performed using RAD 7, a solid state α detector, with RAD H2O accessory. The results show that the radon activities are within the range of 0.19–5.89 Bql−1 with an average value of 0.98...

Radon is the oldest drug used by mankind. Ceremonial donations excavated at the hot radon springs in the Gastein valley, Austria, originate from the younger stone age. Today some 50 000 patients suffering from rheumatic deceases like ankylosing spondilytis are visiting the Radon therapy at Gastein, a few hundred thousands per year all over the world. Other radon therapies are located in Japan a...

The association between lung cancer and exposure to radon decay products has been well established. Despite agreement on this point, there is still some degree of uncertainty regarding characteristics of the exposure-response relationship. The use of studies of underground miners to estimate lung cancer risks due to residential radon exposure depends upon a better understanding of factors poten...

The radon chamber at Bowser-Morner was designed to ensure that the concentration of radon throughout the chamber is uniform. Nevertheless, it is important to demonstrate this uniformity periodically with measurements. To that end, 36 continuous radon monitors were simultaneously deployed in the chamber in a statistically balanced pattern and were exposed for a period of 48 hours. The resulting ...

Introduction: Radioactive material is always present in the environment, and the largest contribution to the inhalation exposure comes from the short half-life decay products of radon. Accordingly, the concentrations of radon were measured in the milk and tea samples collected from Misanmarkets in Iraq. Material and Methods: A total of 2...

background: alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. the biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interaction...