The present review describes the work carried out during the last 20 years in the field of the radioprotective activity and toxicity of several classes of organosilicon and organogermanium compounds (i.e. metallathiazolidines, metalladithioacetals, metallatranes and germathianes).

The goal of combined pharmacological approaches in the treatment of the acute radiation syndrome (ARS) is to obtain an effective therapy producing a minimum of undesirable side effects. This review summarizes important data from studies evaluating the efficacy of combining radioprotective agents developed for administration prior to irradiation and therapeutic agents administered in a post-irra...

The aim of this study was to evaluate the radioprotective and reparative effects of compounds based on aloe vera, zinc, and copper against salivary gland dysfunction in Wistar rats. A total of 150 Wistar rats were randomly divided into 12 groups, in which the animals received aloe vera and/or zinc and copper. In eight of these groups the animals were also subjected to irradiation before or afte...

Radiation therapy (RT) evolved to be a primary treatment modality for cancer patients. Unfortunately, the cure or relief of symptoms is still accompanied by radiation-induced side effects with severe acute and late pathophysiological consequences. Inhibitors of cyclooxygenase-2 (COX-2) are potentially useful in this regard because radioprotection of normal tissue and/or radiosensitizing effects...

The development of radioprotective agents has been a subject of intense research in view of their potential for use within a radiation environment, such as space exploration, radiotherapy and even nuclear war. Since no ideal, safe synthetic radioprotectors are available to date, the search for alternative sources, including plants, has been on-going for several decades. In the Traditional India...

The appropriate dosage of edaravone—a radioprotective agent—and its effect on tumors are unknown. This study evaluated the effects edaravone intestinal injuries and in mice induced by whole body X-ray irradiation. Small mucositis was C3H/HeNSlc using a single dose (15 Gy). Edaravone (15, 30, 100 mg/kg) administered 30 min before irradiation to evaluate protective effect. After 3.5 days, jejunum...

background: from the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. radiation protection concepts and philosophy have been evolving over the past several decades. materials and methods: the radioprotective of effect of aloe vera leaf extract (1000 mg /kg b.wt. orally for 15 consecutive days) has been studied against 6 gy of gamma radiation in ...