Copyright © 1965 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online ISSN: TX 72514 Circulation Research is published by the American Heart Association. 7272 Greenville Avenue, Dallas, 1965;16;309-321 Circ. Res. KENNETH L. ZIERLER Equations for Measuring Blood Flow by External Monitoring of Radioisotopes http://circres.ahajournals.org located on the World Wide Web at:...

The development of positron tomography and ultra-compact cyclotrons has been accelerating the studies on automated and efficient productions of radiopharmaceuticals labeled with short-lived positron emitters (11C, 13N, 150 and 18F) for medical diagnostic use in hospitalsu. Of these radioisotopes, 11C is the most potential for synthesis of various kinds of organic compounds2). 11CO is one of the...

The Vienna Environmental Research Accelerator (VERA) is a dedicated facility for accelerator mass spectrometry (AMS), operated at the University of Vienna since 1996. The principle of AMS with VERA and the advantage of measuring long-lived radioisotopes by atom counting (AMS) rather than decay counting (ß decay) is described. A brief overview on AMS applications is also presented.

BACKGROUND High-energy photon and electron therapeutic beams generated in medical linear accelerators can cause the electronuclear and photonuclear reactions in which neutrons with a broad energy spectrum are produced. A low-energy component of this neutron radiation induces simple capture reactions from which various radioisotopes originate and in which the radioactivity of a linac head and va...

New Authority Over Radioisotopes One set of regulations delegates new authority over radioisotopes to the Nuclear Regulatory Commission (NRC) and is a direct result of testimony submitted by NRC officials to the U.S. House of Representatives Subcommittee on National Security, Emerging Threats, and International Relations and to the U.S. Senate in 2004. In addition to enhanced security measures ...

PURPOSE Throughout the years, the palliative treatment of bone metastases using bone seeking radiotracers has been part of the therapeutic resources used in oncology, but the choice of which bone seeking agent to use is not consensual across sites and limited data are available comparing the characteristics of each radioisotope. Computational simulation is a simple and practical method to study...

Nuclear medicine utilizes radioisotopes to diagnose and in some cases treat disease. Modern instruments can image their accumulation in an organ and provide quantitative data when indicated. The strength of these procedures is in the unique physiologic information they provide, rather than the presentation of precise anatomic detail.

The physical and biological aspects of polonium-210, one of the most hazardous radioisotopes, are summarized. Although this radioisotope is naturally occurring and rare, it received quite a bit of attention after it was used in the 2006 assassination of former Russian Intelligence member Alexander Litvinenko in London. Recent reports on the suspected murder of Yasser Arafat with polonium-210 ar...

We review the following labels used as substitutes for radioisotopes in immunoassay systems: bacteriophages, chemiluminescence precursors, fluorochromes, fluorogens, fluorescence quenchers, enzymes, coenzymes, inhibitors, substrates, various particulates, metal atoms, and stable free radicals. New methods for performing immunoassays with these labels are described where appropriate. Methods tha...

Radioisotopes of elements from all parts of the periodic table find both clinical and research applications in radionuclide molecular imaging and therapy (nuclear medicine). This article provides an overview of these applications in relation to both the radiological properties of the radionuclides and the chemical properties of the elements, indicating past successes, current applications and f...