PURPOSE Although significant decrease in retinal perfusion is usually not observed before all of the cervical arteries became markedly narrowed in patients with Takayasu's disease (TD), we present bilateral glaucomatous optic neuropathy in a patient with TD without any cervical arterial stenosis. METHODS Ophthalmoscopic examination disclosed glaucomatous optic neuropathy in both eyes with 7/1...

Glaucomatous optic neuropathy is characterized by changes in the intrapapillary and parapapillary region of the optic nerve head, including excavation of the optic nerve head and consequent defects in retinal sensitivity with visual field defects and other psychophysical alterations. Clinical evaluation of the optic nerve head has been shown to have a high specificity and good precision for gla...

Quantitative clinical and computed tomographic (CT) measures of Graves' ophthalmopathy were obtained in 76 patients. Significant correlation of several CT parameters of the mid-orbital axial CT slice with optic nerve involvement was established. By means of clinical measures, only limitation of ocular motility was found to correlate with the optic neuropathy. The results suggested that there we...

PURPOSE Focal neurodegeneration of the optic nerve in Leber hereditary optic neuropathy (LHON) is primarily due to a maternally inherited mitochondrial DNA mutation. However, the markedly reduced penetrance of LHON and segregation pattern of visual failure within families implicates an interacting nuclear genetic locus modulating the phenotype. Folate deficiency is known to cause bilateral opti...

We describe the clinical characteristics and early natural history of a form of inflammatory optic neuropathy which is frequently bilateral and often painful, and is characterized by relapses and remissions. MRI scans of the brain are normal and those of the optic nerves often, but not always, show high signal abnormalities which enhance. The symptoms and signs respond well to corticosteroid tr...

PURPOSE Our purpose was to report a case of anterior optic neuropathy with pupillary edema in a patient treated with the TNF-alpha-antagonist adalimumab. METHODS We report the case of a 60-year-old woman with optic neuropathy in 1 eye after 6 months of treatment with adalimumab. RESULTS The patient developed decreased visual acuity of the left eye. The ocular findings were left optic disc s...

Twenty eyes of 10 healthy subjects, 11 eyes of seven patients with low tension glaucoma, and three eyes of three patients with ischaemic optic neuropathy were investigated. Visual evoked responses were recorded under stepwise artificially increased intraocular pressures. The results of the visual evoked response recording (pressure compliance test) allow a clear distinction to be made between h...

Thyroid-associated ophthalmopathy (TAO) is a thyroid hormone imbalance thatmanifests in the eye. The most common TAO Grave’s Disease. could increase theintraocular pressure and cause glaucoma optic neuropathy therefore secondaryglaucoma happen.

OBJECTIVE To demonstrate the development of subfoveal fluid associated with optic disc swelling from nonarteritic anterior ischemic optic neuropathy. METHODS Optical coherence tomographic studies obtained during a 3-year period (October 1, 2003, to December 30, 2006) from 76 patients who developed ischemic optic neuropathy from 2 institutions were evaluated. The presence or absence, and the d...