The present thesis is focused on the development and application of dose response models for radiation therapy. Radiobiological models of tissue response to radiation are an integral part of the radiotherapeutic process and a powerful tool to optimize tumor control and minimize damage to healthy tissues for use in clinical trials. Ideally, the models could work as a historical control arm of a ...

Annually, many people are irradiated for diagnostic and therapeutic purposes. Assessment of radiation dose and its related risks to patients are important issues in radiation protection dosimetry. The complex mathematical calculations of the absorbed and effective doses are now done with computers. The calculations are performed with the help of anthropomorphic computational models of human bod...

Solar radiation is a critical driver of many processes on the earth’s surface. It is an important parameter in ecological process modelling, hydrological modelling and biophysical modelling. However, one of the reasons for solar radiation not that widely being utilised in process models is that it is a difficult parameter to measure for all locations, unlike rainfall that can be measured at sam...

OBJECTIVE To follow-up on earlier studies of the leukaemogenicity of occupational ionising radiation exposure. METHODS We conducted a nested case-control analysis of leukaemia mortality in a pooled cohort of US nuclear workers followed through 2005. Each case was matched to four controls on attained age. Exposures were estimated from available records. General relative risk models were used t...

SouthernWest Africa (SWA) has a large population that relies on highly variablemonsoon rainfall, yet climate models show little consensus over projected precipitation in this region. Understanding of the current and future climate of SWA is further complicated by rapidly increasing anthropogenic emissions and a lack of surface observations. Using multiple satellite observations, the ERA-Interim...

Salen Mn complexes, including EUK-134, EUK-189 and a newer cyclized analog EUK-207, are synthetic SOD/catalase mimetics that have beneficial effects in many models of oxidative stress. As oxidative stress is implicated in some forms of delayed radiation injury, we are investigating whether these compounds can mitigate injury to normal tissues caused by ionizing radiation. This review describes ...

Hourly global solar radiation in a weather file is one of the significant parameters for improving building energy performance analyses using simulation programs. However, most weather stations worldwide are not equipped with solar radiation sensors because they tend to be difficult to manage. In South Korea, only twenty-two out of ninety-two weather stations are equipped with sensors, and ther...

In this review, we discuss the use of a variety of 3-D models (particularly 3-D skin, lung, breast and endothelial) in radiobiological research and highlight the differences in responses compared to 2-D culturing conditions (monolayers). We review the characteristics of existing 3-D models and aim to point out the substantial advantages 3-D cultures provide for modern radiobiology. In particula...

In this study, several regression models were employed to estimate global solar radiation from commonly available meteorological data such as sunshine duration, temperature, precipitation, and cloud cover for 34 meteorological stations of Bangladesh. The models studied were calibrated using five meteorological stations that are providing global solar radiation as well as other meteorological da...