نتایج جستجو برای: rac1 gtp

تعداد نتایج: 20573  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2014
Nobuhiro Yaoita Ryutaro Shirakawa Yoshihiro Fukumoto Koichiro Sugimura Satoshi Miyata Yutaka Miura Kotaro Nochioka Masanobu Miura Shunsuke Tatebe Tatsuo Aoki Saori Yamamoto Kimio Satoh Tomohiro Kimura Hiroaki Shimokawa Hisanori Horiuchi

OBJECTIVE Chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease that is distinct from pulmonary arterial hypertension (PAH). Although CTEPH is characterized by obstruction of major pulmonary artery because of chronic thrombus, it remains unclear whether CTEPH is associated with prothrombotic condition. APPROACH AND RESULTS In addition to conventional markers, GTP-bound leve...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2001
P Penzes R C Johnson V Kambampati R E Mains B A Eipper

The actin cytoskeleton, essential for neuronal development, is regulated in part by small GTP binding proteins of the Rho subfamily. Kalirin-9, with two Rho subfamily-specific GDP/GTP exchange factor (GEF) domains, localizes to neurites and growth cones of primary cortical neurons. Kalirin-9 overexpression in cultured cortical neurons induces longer neurites and altered neuronal morphology. Exp...

2017
Kan Tanabe Yoshinari Shinsato Tatsuhiko Furukawa Yoshiaki Kita Kazuhito Hatanaka Kentaro Minami Kohichi Kawahara Masatatsu Yamamoto Kenji Baba Shinichiro Mori Yasuto Uchikado Kosei Maemura Akihide Tanimoto Shoji Natsugoe

To establish treatments to improve the prognosis of cancer patients, it is necessary to find new targets to control metastasis. We found that expression of FilaminC (FLNC), a member of the actin binding and cross-linking filamin protein family is correlated with lymphatic invasion and lymphatic metastasis in esophageal squamous cell carcinoma (ESCC) by increasing cell motility through activatio...

Journal: :Journal of cell science 2002
Candace Shelly Roman Herrera

The SGK1 protein belongs to the AGC gene family of kinases that are regulated by phosphorylation mediated by PDK1. SGK1 regulation is accomplished by several pathways including growth-factor and stress-mediated signaling. We have expanded the analysis of SGK1 regulation in epithelial cells. We used HA-tagged SGK1 to transiently transfect MDCK cells and study the regulation of SGK1 upon stimulat...

Journal: :Molecular biology of the cell 1997
R T Müller U Honnert J Reinhard M Bähler

myr 5 is an unconventional myosin (class IX) from rat that contains a Rho-family GTPase-activating protein (GAP) domain. Herein we addressed the specificity of the myr 5 GAP activity, the molecular mechanism by which GAPs activate GTP hydrolysis, the consequences of myr 5 overexpression in living cells, and its subcellular localization. The myr 5 GAP activity exhibits a high specificity for Rho...

2013
Assaf Rudich Amira Klip

In spite of numerous and key advances in our understanding of insulin signaling, the molecular basis for impaired insulin-stimulated glucose uptake underlying insulin resistance remains unclear. Because skeletal muscle accounts for the majority of glucose utilization in the postprandial insulin-regulated state, defects in insulin action in muscle can determine whole-body glucose utilization. In...

Journal: :The Journal of Cell Biology 2000
Allison L. Berrier Anthony M. Mastrangelo Julian Downward Mark Ginsberg Susan E. LaFlamme

Attachment of many cell types to extracellular matrix proteins triggers cell spreading, a process that strengthens cell adhesion and is a prerequisite for many adhesion-dependent processes including cell migration, survival, and proliferation. Cell spreading requires integrins with intact beta cytoplasmic domains, presumably to connect integrins with the actin cytoskeleton and to activate signa...

Journal: :The Journal of biological chemistry 2004
Balazs Debreceni Yuan Gao Fukun Guo Kejin Zhu Baoqing Jia Yi Zheng

Rho family GTPases play important roles in a variety of cellular processes, including actin cytoskeleton reorganization, transcription activation, and DNA synthesis. Dominant negative mutants of Rho GTPases, such as T17NRac1, that block the endogenous Rho protein activation by sequestering upstream guanine nucleotide exchange factors (GEFs) have been widely used to implicate specific members of...

Journal: :Cancer research 2006
Mitsutoshi Nakada Kelsey L Drake Satoko Nakada Jared A Niska Michael E Berens

Eph receptor tyrosine kinases are involved in nervous system development. Eph ligands, termed ephrins, are transmembrane proteins that bind to Eph receptors, the mutual activation of which causes repulsive effects in reciprocally contacting cells. Previously, we showed that overexpression of EphB2 in glioma cells increases cell invasion. Here, expression profiles of ephrin-B family members were...

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