A molecular epidemiological study of the rabies virus currently prevalent in France was carried out by directly sequencing polymerase chain reaction-amplified genes. The rabies virus pseudogene psi was chosen as the most divergent genomic area, and as such the best 'clock' for measuring virus evolution. Sequence comparisons between 12 wild rabies virus isolates indicated strong conservation wha...

  Introduction : Rabies is a disease that has been known since antiquity. It is a highly fatal acute disease of the central nervous system caused by a lyssavirus. Prior to the discovery of the rabies vaccine, rabies-infected individuals fell victim to the delusions and superstitions associated with this disease. Though it has been neglected in many regions of the world, rabies remains one ...

Background: Investigated the fatality in bovines infected with rabies virus through dog bite, that have undergone post bite therapy. The site of close to brain was an important factor and reason behind fatality. Methods: findings from cattle naturally Rabies vaccinated shots anti-rabies vaccine were considered for present study. cases i.e., 20 (out total 58 reported) bovines, Bidar, Karnataka M...

Rabies is a subject of public health concern in Ethiopia. The current rabies profile in Ethiopia shows 12 exposure cases/ 100,000 population and 1.6 rabies deaths /100,000 populations primarily because of canine rabies virus transmission exacerbated by uncontrolled stray dog population. The objective of this piece of work was to study the molecular epidemiology of rabies virus based on nucleoti...

The role of brain neurotransmitter transport processes in rabies virus infection of neurons was examined. The uptake and release of gamma-amino-n-butyric acid (GABA) in rabies virus-infected embryonic rat cortical neurons was assayed using tritiated ligands. A 45% reduction of [3H]GABA uptake was observed 3 days post-infection, when a maximum level of infectious particle release occurs. At this...

We wanted to develop a therapeutic approach against rabies disease by targeting the lyssavirus transcription/replication complex. Because this complex (nucleoprotein N-RNA template processed by the L polymerase and its cofactor, the phosphoprotein P) is similar to that of other negative-strand RNA viruses, we aimed to design broad-spectrum antiviral drugs that could be used as a complement to p...

To evaluate the role of apoptosis in rabies encephalitis in humans and canines infected with wild-type street virus, in comparison with rodent model infected with street and laboratory passaged CVS strain, we studied postmortem brain tissue from nine humans, six canines infected with street rabies virus, and Swiss albino mice inoculated intramuscularly (IM) and intracerebrally (IC) with street ...

INTRODUCTION Bats are one of the most important reservoirs and vectors of the rabies virus in the world. METHODS From 1988 to 2003, the Zoonosis Control Center in São Paulo City performed rabies diagnosis on 5,670 bats by direct immunofluorescent test and mouse inoculation test. Blood samples were collected from 1,618 bats and the sera were analyzed using the rapid fluorescent focus inhibitio...

The small Indian mongoose (Herpestes auropunctatus) was introduced to several Caribbean Islands to control rat (Rattus spp.) damage to sugarcane plantations. Mongooses failed at suppressing rat populations and are now considered pests throughout most of their introduced range. Importantly, mongooses are rabies reservoirs on several Caribbean Islands. In Puerto Rico, mongooses have been implicat...