The tuning parameter selection strategy for penalized estimation is crucial to identify a model that both interpretable and predictive. However, popular strategies (e.g., minimizing average squared prediction error via cross-validation) tend select models with more predictors than necessary. A simple yet powerful cross validation proposed which based on maximizing the correlation between observ...

A bstract We propose a new construction of the supergravity inflation as an UV completion Higgs- R 2 inflation. In dual description -supergravity, we show that there appear chiral superfields containing scalaron or sigma field in Starobinsky inflation, which unitarizes supersymmetric Higgs with large non-minimal coupling up to Planck scale. find successful slow-roll is achievable Higgs-sigma sp...

For simplicity, we adopt the following convention: x, x0, y, y0, r are real numbers, z, z0 are elements of R2, f , f1, f2 are partial functions from R2 to R, R is a rest, and L is a linear function. Let us note that every rest is total. Let f be a partial function from R2 to R and let z be an element of R2. The functor pdiff1(f, z) yielding a function from R2 into R is defined as follows: (Def....

In this paper, we study Raychaudhuri's equation in the background of R + βR 2 gravity with a phenomenological matter (ρ ∝ a(t) −n). We conclude that even though the Strong Energy Condition (S.E.C.) for Einstein's gravity, which guarantees singularity, is n ≥ 2 for ρ ∝ a(t) −n , a perturbative analysis of Raychaudhuri's equation in the background of R+βR 2 gravity reveals that the big bang singu...

Introduction: Targeted nanoparticles have been developed as contrast agents for MRI to detect molecules and cells in vivo. A fundamental constraint in nanoparticle agents and, indeed, in many MRI contrast agents, is that they are not readily distinguished from each other after delivery. This constraint has been recently overcome in specific, fabricated agents by tuning off-resonance and exchang...

The small subunit of Escherichia coli ribonucleotide reductase (R2) is a homodimeric (betabeta) protein, in which each beta-peptide contains a diiron cluster composed of two inequivalent iron sites. R2 is capable of reductively activating O(2) to produce a stable tyrosine radical (Y122*), which is essential for production of deoxyribonucleotides on the larger R1 subunit. In this work, the param...

Transposons, or transposable elements, are the major components of genomes in most eukaryotes. Some groups of transposons have developed target specificity that limits the integration sites to a specific nonessential sequence or a genomic region to avoid gene disruption caused by insertion into an essential gene. R2 is one of the most intensively investigated groups of sequence-specific non-LTR...

Aims This study aimed to assess functional course in elderly patients undergoing transcatheter aortic valve implantation (TAVI) and to find predictors of functional decline. Methods and results In this prospective cohort, functional course was assessed in patients ≥70 years using basic activities of daily living (BADL) before and 6 months after TAVI. Baseline EuroSCORE, STS score, and a frailty...

The effect of majonoside-R2 on morphine- and U-50,488H-induced antinociception was examined by the tail-pinch test in mice and compared with that of diazepam. Majonoside-R2 and diazepam inhibited the morphine- and U-50,488H-induced antinociception, and the actions were antagonized by the benzodiazepine receptor antagonist flumazenil and the GABA-gated CI- channel blocker picrotoxin. Diazepam bu...