PURPOSE A series of quinazoline isatine hybrid derivatives were designed and their molecular docking studies were performed to ascertain the inhibition of EGFR by these hybrids. METHODS Molecular modelling and docking methods were employed to design and synthesize the molecules. The compounds which showed good binding properties were synthesized and characterized. After structural confirmatio...

The asymmetric unit of the title compound, C15H12ClN3, contains two independent mol-ecules. The quinazoline ring system in each is essentially planar, with maximum deviations of 0.025 (16) and 0.0171 (16) Å. The dihedral angles between quinazoline ring systems and the phenyl rings are 88.25 (8) and 85.28 (16)° in the two independent mol-ecules. In the crystal, alternating independent mol-ecules...

The present work describes convenient synthesis of the novel Schiff bases 4, 5 and 6 by reaction each previously synthesized quinazolinones 1, 2 3 with p-methoxybenzaldehyde. [2+2] Cycloaddition Reaction former within phenylisothiocyanate affording azatedine derivatives 7 8. Also, quinazolines 1 could be reacted α-bromoglucose tetraacetate giving peracetylated N-glycosides 9 10 which were then ...

A series of 2-(naphthalen-1-yl)-methyl-6-arylimidazo[2,1-b][1,3,4]thiadiazole derivatives was prepared and studied for cytotoxicity against murine leukemia L1210, human cervix carcinoma HeLa, T-lymphocyte CEM cell lines. The preliminary study showed that compounds 5g, 6g, 7a-c, 7e, 8e were more potent among the tested compounds. pharmacokinetic properties all then investigated with FAF-Drugs, a...