The development of the first enantio-, diastereo-, and regioselective iridium-catalyzed allylic alkylation reaction of prochiral enolates to form an all-carbon quaternary stereogenic center with an aliphatic-substituted allylic electrophile is disclosed. The reaction proceeds with good to excellent selectivity with a range of substituted tetralone-derived nucleophiles furnishing products bearin...

An efficient method for the diastereo- and enantioselective construction of vicinal all-carbon quaternary stereocenters through palladium-catalyzed decarboxylative cycloaddition of vinylethylene carbonates with activated Michael acceptors was developed. By using a palladium complex generated in situ from [Pd2(dab)3]⋅CHCl3 and a phosphoramidite ligand as a catalyst under mild reaction conditions...

A highly regio- and stereospecific rhodium-catalyzed allylic alkylation of tertiary allylic alcohol derivatives with a cyanohydrin pronucleophile is described. This direct and operationally simple protocol provides a fundamentally novel approach toward the synthesis of α-quaternary substituted ketones and circumvents many of the inherent problems associated with conventional enolate alkylation ...

Pd-catalyzed enantioselective alkylation in conjunction with further synthetic elaboration enables the formal total syntheses of a number of "classic" natural product target molecules. This publication highlights recent methods for setting quaternary and tetrasubstituted tertiary carbon stereocenters to address the synthetic hurdles encountered over many decades across multiple compound classes...

In this note, we establish a mass formula for self-orthogonal codes over Z p 2 , where p is a prime. As a consequence, an alternative proof of the known mass formulas for self-dual codes over Z p 2 is obtained. We also establish a mass formula for even quaternary codes, which includes a mass formula for Type II quaternary codes as a special case.

In this letter, a method to construct good binary and quaternary error correcting codes, called complex Hadamard codes, based on a complex Hadamard matrix is presented. The related properties of the codes are analyzed. In addition, through the operation in Z4 domain, a new simplex soft-decision decoding algorithm for the complex Hadamard codes is also proposed. key words: complex Hadamard matri...

The first highly enantioselective iridium-catalyzed allylic alkylation that provides access to products bearing an allylic all-carbon quaternary stereogenic center has been developed. The reaction utilizes a masked acyl cyanide (MAC) reagent, which enables the one-pot preparation of α-quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity. The utility of these ...

A general reconnaissance of the remnants of Pleistocene high sea-level stands was conducted along the Sonora coast, between the Rio Colorado delta and the Guaymas area, to determine the neotectonic comportment of the mainland margin of the Gulf of California plate boundary. The generally low relief of this coastal region and the extensive cover of the late Quaternary eolian sands (in the northe...

The parallel branching program machine (PBM128) consists of 128 branching program machines (BMs) and a programmable interconnection. To represent logic functions on BMs, we use quaternary decision diagrams. To evaluate functions, we use 3-address quaternary branch instructions. We emulated many benchmark circuits on PBM128, and compared its memory size and computation time with the Intel’s Core...

Assessment of the quaternary structure of membrane proteins by PAGE has been problematic owing to their relatively poor solubility in non-dissociative detergents. Here we report that several membrane proteins can be readily solubilized in their native quaternary structure with the use of the detergent perfluoro-octanoic acid (PFO). Further, PFO can be used with PAGE, thereby providing a novel, ...