BACKGROUND AND PURPOSE Intractable epilepsy is a well-recognized complication following head trauma, and many factors have been implicated in its pathogenesis. This study was performed to determine the severity of tissue damage after severe head injury as assessed with magnetization transfer (MT) MR imaging and the relationship of this damage with seizure intractability. METHODS Forty-four pa...

INTRODUCTION: While most clinical studies using magnetization transfer (MT) imaging have been performed at 1.5T, high resolution-MT imaging (hr-MT) is feasible at 3T. Higher field enables efficient acquisition with improved conspicuity of brain structures (1). Hr-MT has considerable potential for investigating neurological disorders affecting small brain structures such as early stage Alzheimer...

OBJECTIVE To validate the use of the magnetization transfer ratio (MTR) as a practical imaging marker of demyelination and remyelination in acute multiple sclerosis lesions. DESIGN Case study. SETTING University hospital multiple sclerosis clinic. Patients Six patients with relapsing-remitting multiple sclerosis and acute gadolinium-enhancing lesions were studied serially using a quantitati...

Recent observations of switching of magnetic domains in ferromagnetic metals by circularly polarized light, so-called all-optical helicity dependent switching, has renewed interest in the physics that governs the interactions between the angular momentum of photons and the magnetic order parameter of materials. Here we use time-resolved-vectorial measurements of magnetization dynamics of thin l...

PURPOSE Our aim was to assess whether presumed histologic heterogeneity of age-related white matter hyperintensities (WMH) is reflected in quantitative magnetization transfer imaging measures. MATERIALS AND METHODS From a group of patients participating in a double-blind placebo-controlled multicenter study on the effect of pravastatin (PROSPER), we selected 56 subjects with WMH. WMH were cla...

INTRODUCTION In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we inve...

BACKGROUND AND PURPOSE Huntington's disease (HD) is a chronic progressive neurodegenerative disorder with a long presymptomatic period that opens a window for potential therapies aimed at neuroprotection. Neuroimaging offers the potential to monitor disease-related progression of the disease burden (DB) using model-based magnetization transfer imaging. MATERIALS AND METHODS We have conducted ...

INTRODUCTION In this study of human cartilage, we tested the hypothesis that the magic angle effect is reduced more in MT-weighted images than in T2-weighted images. Articular cartilage has three structural zones distinguished by collagen fiber orientations: superficial zone, transitional zone, and radial zone. When collagen fibers are oriented at 54.7°with respect to the main magnetic field of...

Chemical exchange saturation transfer (CEST) is an emerging MRI contrast mechanism that is capable of noninvasively imaging dilute CEST agents and local properties such as pH and temperature, augmenting the routine MRI methods. However, the routine CEST MRI includes a long RF saturation pulse followed by fast image readout, which is associated with high specific absorption rate and limited spat...