In Parkinson Disease (PD) as well as in stroke research there is an urgent need to both optimize the use of resources (number of patients, costs, and time) and select potential effective neuroprotective agents. The processes used to identify and study new therapies for PD may be applicable to the search for new therapies in stroke. The National Institute of Neurological Disorders and Stroke (NI...

INTRODUCTION King's College Hospital criteria are currently used to select liver transplant candidates in acetaminophen-related acute liver failure (ALF). Although widely accepted, they show a poor sensitivity in predicting pre-transplant mortality and cannot predict the outcome after surgery. In this study we aimed to develop a new prognostic score that can allow patient selection for liver tr...

Dr Hinshaw: Welcome to the general session entitled “When Do We Stop, and How Do We Do It? Medical Futility and Withdrawal of Care.” This symposium is one of an ongoing series of symposia focused on palliative care organized by the Work Group for Surgical Palliative Care, jointly sponsored by the College and the Robert Wood Johnson Foundation. We are fortunate to be able to make this a highly i...

Using full-game databases and optimized tree-search algorithms, the game of Kalah is solved for several starting configurations up to 6 holes and 5 counters per hole. The main search algorithm used was iterative-deepening MTD(f). Major search enhancements were move ordering, transposition tables, futility pruning, enhanced transposition cut-off, and endgame databases.

Clinical trials have become the preeminent tool for investigating new diagnostic, therapeutic, and preventive treatment strategies. During these trials, periodic interim data analyses are conducted by data monitoring committees (DMCs) to ensure participant safety. If accumulated data indicate harm to participants, clear evidence of superior efficacy, or futility of collecting additional data, s...

Ethical issues in the critical care unit frequently arise in children with neurological problems. These ethical issues frequently challenge our medical management of such cases and can be quite problematic. This article reviews key ethical issues that may arise including informed consent, futility, justice/rationing, clinical research conduct and the severely compromised patient who is in eithe...