Purpose of the study Lersivirine (LRV) is a next-generation NNRTI currently under investigation in two Phase IIb studies at doses of 500 1000 mg QD. In vitro analyses suggest that LRV is a weak Ikr and CA 2+ channel blocker. However, doseranging Phase I studies have not shown prolongation of QTc interval to date. This study was performed to investigate the effect of a supratherapeutic dose of L...

PURPOSE Ventricular repolarization is assessed using the QT interval corrected by the heart rate (QTc) via an electrocardiogram (ECG). Prolonged QTc is associated with an increased risk of arrhythmias and cardiac mortality. As there have been few reports regarding the effects of hyperthyroidism on ventricular repolarization, we studied the association between serum free thyroxine (free T4 [fT4]...

AIMS Identification of a prolonged, corrected QT (QTc) interval in athletes may be a recommendation for disqualification from competitive sports. However, the prevalence and diagnostic significance of an isolated prolonged QTc in asymptomatic athletes without familial disease is unknown. METHODS AND RESULTS Between 1996 and 2006, 2000 elite athletes (mean age, 20.2 years) underwent 12-lead EC...

BACKGROUND AND PURPOSE QTc interval prolongation is a predictor of cardiovascular morbidity and mortality in general populations and in patients with diabetes. The aim of this study was to investigate the predictors of stroke in patients with type 2 diabetes, with particular emphasis on the independent role of QT interval parameters. METHODS We carried out a long-term follow-up study with 471...

Patients with schizophrenia are at higher risk for medical illnesses than people in the general population. The risk of atherosclerosis and cardiac death in these patients is markedly higher and parallels the severity of the disease. Last but not least, one should mention the role of the treating physician in the unwanted occurrence of abnormal QTc prolongation and SCD, mostly resulting from to...

Understanding the factors influencing a drug's potential to prolong the QTc interval on an electrocardiogram is essential for the correct evaluation of its safety profile. To explore the effect of dosing time on drug-induced QTc prolongation, a randomized, crossover, clinical trial was conducted in which 12 healthy male subjects received levofloxacin at 02:00, 06:00, 10:00, 14:00, 18:00, and 22...

OBJECTIVE Patients with familial dysautonomia have an increased risk of sudden death. In some patients with familial dysautonomia, sympathetic cardiac dysfunction is indicated by prolongation of corrected QT (QTc) interval, especially during stress tests. As many patients do not tolerate physical stress, additional indices are needed to predict autonomic risk. In familial dysautonomia there is ...

Background: Azithromycin maintenance therapy is widely used in cystic fibrosis (CF), but little known about its long-term safety. We investigated whether chronic azithromycin use safe regarding renal function, hepatic cell toxicity and QTc-interval prolongation.Methods: Adult CF patients (72 using for a cumulative period of 364.8 years 19 controls, 108.8 years) from two CF-centers the Netherlan...