نتایج جستجو برای: qt changes
تعداد نتایج: 885956 فیلتر نتایج به سال:
Mutations in cardiac voltage-gated K+ channels cause long QT syndrome (LQTS) and sudden death. We created a transgenic mouse with a long QT phenotype (Kv1DN) by overexpression of a truncated K+ channel in the heart and investigated whether the dominant negative effect of the transgene would be overcome by the direct injection of adenoviral vectors expressing wild-type Kv1.5 (AV-Kv1.5) into the ...
The clinical importance of the long QT interval syndrome lies in its association with malignant ventricular dysrhythmias which are usually amenable to treatment with either drugs or cardiac pacing. The QT interval extends from the beginning of the QRS complex (whether the initial component is a Q or an R wave) to the end of the T wave. It therefore represents the algebraic sum of the individual...
Photosynthetic organisms have to tolerate rapid changes in light intensity, which is facilitated by non-photochemical quenching (NPQ) and involves modification of energy transfer from light-harvesting complexes (LHC) to the photosystem reaction centres. NPQ includes dissipating excess light energy to heat (qE) and the reversible coupling of LHCII to photosystems (state transitions/qT), which ar...
PURPOSE Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity. EXPERIMENTAL DESIGN ABCB1-related romidepsin transport kinet...
Objective: Increased risk for arrhythmias and the association between arrhythmogenic markers symptom severity in antipsychotic-free patients with schizophrenia are understudied. We evaluated changes P-wave dispersion (PWD), corrected QT interval (QTc), QTc (QTcd), JT (JTc), JTc (JTcd), Tpeak-Tend (Tp-e), Tp-e/QT ratio. Method: Fifty-six who were at least 1 month 56 age- gendermatched healthy co...
Data of a large clinical study were used to investigate how much are the QT/RR patterns in healthy subjects curved and whether these curvatures differ between women and men. Daytime drug-free 12-lead Holter recordings were repeated 4 times in each of 176 female healthy subjects and 176 male healthy subjects aged 32.7 ± 9.1 yr. In each of the subjects, up to 1,440 carefully verified QT interval ...
The dynamics and homogeneity of the QT interval have been used as indicators of susceptibility to ventricular arrhythmias. We determined the relationship between QT intervals and heart rate during exercise testing and subsequent recovery in 18 healthy children. The QT intervals were measured to the apex (early QT), to the end (total QT), and from the apex to the end of the T wave (late QT) (inh...
The relationship between a prolonged QT interval and an increased risk of sudden death has been extensively explored in familial long QT syndrome, sudden infant death, and ischemic heart disease (1–3). Several recent studies also describe the relation between corrected QT interval (QTc) prolongation, diabetes complications, and an increased mortality in adults (4,5). We recently described QTc p...
OBJECTIVES To improve the diagnostic criteria of the congenital long QT syndrome in borderline cases we examined rate adaptation of ventricular repolarization phases during exercise and subsequent recovery in children with the long QT syndrome and controls. METHODS Nineteen children with definite long QT syndrome and 19 healthy controls underwent exercise testing. QT intervals were measured t...
There has been an increasing focus on drug induced QT prolongation including research on drug development and QT prolongation, following the removal of drugs due to torsades de pointes (TdP). Although this has improved our understanding of drug-induced QT prolongation there has been much less research aimed at helping clinicians assess risk in individual patients with drug induced QT prolongati...
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