Diabetic peripheral neuropathy (DPN) is a frequent complication of type 2 diabetes mellitus (DM) and may involve small and large peripheral nerve fibers. Recent evidence suggests a role of cytokines in DPN. The paper is aimed at exploring whether the serum concentration of cytokines is associated with small and large nerve fiber function and with neuropathic pain (NP). We recruited a group of 3...

The spinothalamic pathway mediates sensations of temperature, pain, and touch. These functions seem impaired in children with Down syndrome (DS), but have not been extensively examined in adults. The objective of the present study was to compare the spinothalamic-mediated sensory functions between adults with DS and adults from the general population and to examine in the DS group the relations...

Mango production in the South of Senegal is exposed to intensive rainfall from late May to October, with high temperature and moisture levels. These conditions are conducive for the development of anthracnose caused by Colletotrichum gloeosporioides (sensu lato) and produce a need for adequate control measures. Anthracnose disease causes preand postharvest fruit spots, fruit rot, and premature ...

Extraordinary progress in quantum sensors and technologies opens new avenues for exploring the Universe testing assumptions forming basis of modern physics. This QST focus issue: on new-physics discoveries is a next-decade roadmap developing wide range towards It covers next generation various technologies, including atomic nuclear clocks, diamond-based magnetometers, atom laser interferometers...

BACKGROUND Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) have sufficient scientific support for their use as tissue protectors. Preliminary studies suggest that their angiotensin-II type 2 receptor (AT2R)-blocking properties have a beneficial profile in the treatment of neuropathic pain. OBJECTIVES The purpose of the current study was to quantify the ...

Abstract Background Hereditary transthyretin (ATTRv) amyloidosis is a rare, autosomal dominant, and devastating disease. If untreated, the disease fatal within 4–15 years from onset. Thus, diagnosis in early stages of ATTRv crucial to start treatment prevent or delay progression. However, symptomatic TTR gene mutation carriers may be challenging. Purpose We aimed identifying indexes cardiac and...

BACKGROUND Somatosensory profiling in affected and non-affected body regions can strengthen our insight regarding the underlying pain mechanisms, which can be valuable in treatment decision making and to improve outcomes, in patients with degenerative lumbar spine disorders pre-surgery. The aim was to describe somatosensory profiles in patients with degenerative lumbar spine disorders, to ident...