نتایج جستجو برای: pyruvate kinase
تعداد نتایج: 238659 فیلتر نتایج به سال:
Type L pyruvate kinase from mouse liver has been studied. The enzyme is strongly inhibited by low concentrations of copper ions, and the inhibition is reversed by fructose 1,6diphosphate. In the absence of inhibitor, fructose 1,6diphosphate also increases the pyruvate kinase activity at pH values higher than 7. Furthermore, the Cu++ inhibition is pH and K+ concentration dependent. Plots of reac...
Although considerable progress has been made toward understanding glioblastoma biology through large-scale genetic and protein expression analyses, little is known about the underlying metabolic alterations promoting their aggressive phenotype. We conducted global metabolomic profiling on patient-derived glioma specimens and identified specific metabolic programs differentiating low- and high-g...
The mechanism of action of structurally distinct pyruvate dehydrogenase kinase (PDK) inhibitors was examined in assays with experimental contexts ranging from an intact pyruvate dehydrogenase complex (PDC) with and without supplemental ATP or ADP to a synthetic peptide substrate to PDK autophosphorylation. Some compounds directly inhibited the catalytic activity of PDKs. Some of the inhibitor c...
The phylogeny and substitution rates of the mammalian X chromosome-located and autosomal phosphoglycerate kinase and pyruvate dehydrogenase genes were investigated. Compatibility analysis was used to show reticulate evolution in these genes. Analysis of the marsupial, mouse, and human phosphoglycerate kinase genes suggests that at least two recombination events have taken place, one occurring a...
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