Mibyou has been defined in traditional oriental medicine as a certain physiological condition whereby an individual is not ill but healthy; it also often referred to sub-healthy condition. In society focused on longevity, “Mibyou-care” becomes of primary importance for healthy lifespan expenditure. Functional foods can play crucial roles Mibyou-care; thus, the search novel resources functional ...

The pro-apoptotic Bax and Bak proteins are considered central to apoptosis, yet apoptosis occurs in their absence. Here, we asked whether the mitochondrial protein VDAC1 mediates apoptosis independently of Bax/Bak. Upon screening a fungal secondary metabolite library for compounds inducing apoptosis in Bax/Bak-deficient mouse embryonic fibroblasts, we identified cyathin-R, a new cyathane diterp...

In 1956 Mauzerall and Granick (1) published a method for the calorimetric determination of a-aminoketones that depended on coupling of an a-aminoketone with acetylacetone to form a pyrrole with a free Q! position. The Ehrlich reagent, p-dimethylaminobenzaldehyde in acid, reacted at the CY position of this pyrrole to form a highly colored compound. This method made possible the determination of ...

Pyrroles are important compounds present in biological systems, used for drug synthesis and material chemistry. A typical strategy the pyrrolic ring formation is centered on Paal–Knorr reaction, where 1,4-dicarbonyl react with amines giving N-substituted pyrrole derivatives. Often, main problem of this approach availability appropriate carbonyl compounds. Here, we report a sustainable carboxyli...

A specific assay for 5-aminolaevulinate synthase activity is described, with a sensitivity comparable with that of radiochemical assays. It is based on measurement by g.l.c. with electron-capture detection of the pentafluorobenzyl ester of the ethyl acetoacetate pyrrole derivative of 5-aminolaevulinic acid, and of the corresponding compound from 6-amino-5-oxohexanoic acid used as internal stand...

Twenty-eight novel clorobiocin derivatives obtained from mutasynthesis experiments were investigated for their inhibitory activity towards Escherichia coli DNA gyrase and for their antibacterial activities towards clinically relevant gram-positive and gram-negative bacteria in comparison to novobiocin and clorobiocin. Clorobiocin was the most active compound both against E. coli DNA gyrase in v...