ii DEDICATION I would like to dedicate this thesis to my husband Chris and my mother Phyllis. Without your unending love, support and patience none of this would have been possible. iii ACKNOWLEDGEMENTS First, I must thank my advisor, Jennifer Wiley. Throughout my graduate career Jenny has always had my best interests in mind. She worked hard to make sure her students were supported both intell...

This work presents episodes of first generation information systems development in Sweden using two particular computers, ALWAC IIIE, during the period 1957–1961, and Univac III during 1963–1964. The ALWAC IIIE at ADB Institute, Gothenburg, was used for technical as well as for administrative applications. Another episode concerns reengineering of an inventory management application; it used th...

UNLABELLED Multiple myeloma, also known as Kahler's disease or myelomatosis, is a type of cancer that begins in plasma cells. It is the second most common hematologic malignancy (13%) and accounts for 1% of all cancers. A mnemonic sometimes used to remember the common tetrad of multiple myeloma is CRAB: C = Calcium (elevated), R = Renal failure, A = Anemia, B = Bone lesions. CASE REPORT We pr...

Uz.Dr.Bengü Nisa AKAY Ankara Üniversitesi Tıp Fakültesi İbni Sina Hastanesi Deri ve Zührevi Hastalıkları Anabilim Dalı Samanpazarı 06100 Ankara Türkiye Phone : +90 312 508 25 58 E-mail Address : [email protected] Pitted keratolysis is a superficial bacterial infection of the skin. Corynebacteria infection of the skin is generally the cause although other bacteria have been isolated. Clinical...

Introduction: Recently, dried blood spot (DBS) sampling method has turned out to be a promising microsampling technique for use in preclinical studies of animals and humans in order to obtain matrix samples. With this technique, small-molecule PK characterization with LC-MS/MS has become simpler and faster. Blood sample volumes as low as 15-20 ul containing the drug are collected and applied to...

Presumed ocular histoplasmosis syndrome (POHS) is a clinical entity that is characterized by small, round, discrete, macular or mid peripheral atrophic (punched out) chorioretinal lesions (histo spots), peripapillary scarring, choroidal neovascularization (CNV), and the absence of anterior uveitis and vitritis. Diagnosis of this disorder is based upon characteristic clinical findings and a posi...

AIM To time the onset of cytomegalovirus (CMV) infection in patients (n = 39) with CMV associated neonatal cholestasis by analysing CMV DNA on Guthrie cards sampled at 3 days of age. METHODS CMV infection was diagnosed by serology/urine isolation or by CMV DNA detection (polymerase chain reaction) in liver biopsy specimens. In order to time the infection dry blood filter paper discs were punc...

Four patients with nicorandil induced ulceration are described, and the literature on the subject is reviewed. Nicorandil induced ulcers are very painful and distressing for patients. Clinically they appear as large, deep, persistent ulcers that have punched out edges. They are poorly responsive to topical steroids and usually require alteration of nicorandil treatment. The ulceration tends to ...