BACKGROUND Pulmonary embolism (PE) is a relatively common and potentially life threatening clinical condition with estimated prevalence to be 0.4%. Early diagnosis of PE followed by adequate treatment reduces the risk of major complications. Multislice computed tomography pulmonary angiography (CTPA) currently constitutes an imaging modality of choice in patients with suspicion of PE. Computed ...

We present a case of leaking mycotic aneurysm abdominal aorta complicated by infective endocarditis in young boy 14 years age. This with history rheumatic heart disease vegetations on mitral valve and severe regurgitation landed up complications like femoral artery thrombo embolism followed an aortic contained rupture. was successfully managed addressing two problems i.e. repair single sitting.

Systemic amyloidosis is a rare clinical disorder and can lead to single organ or fatal multiple organ failure, heart and kidneys are the most affected organs. Currently, there are no relevant guidelines and recommendations about the treatment of systemic amyloidosis. Ischemic stroke is an uncommon complication of systemic amyloidosis and patients with systemic amyloidosis may carry a worse prog...

Platelet activation at sites of vascular injury is critical for the formation of a hemostatic plug which limits excessive blood loss, but also represents a major pathomechanism of ischemic cardioand cerebrovascular diseases. Although currently available antiplatelet therapies have proved beneficial in preventing the recurrence of vascular events, their adverse effects on primary hemostasis emph...

Coronary artery thrombosis and ischemic stroke are often initiated by the disruption of an atherosclerotic plaque and consequent intravascular platelet activation. Thus, antiplatelet drugs are central in the treatment and prevention of the initial, and subsequent, vascular events. However, novel pharmacological targets for platelet inhibition remain an important goal of cardiovascular research ...