The regular accumulation of nanoparticles in the liver makes them hepatotoxic and decreases the circulation time, thus reducing their therapeutic effect. Resolving this problem will be significant in improving bioavailability and reducing side effects. In this study, we reduced the phagocytosis of epirubicin (EPI)-loaded folic acid-conjugated pullulan acetate (FPA/EPI) nanoparticles by Kupffer ...

INTRODUCTION Size-exclusion chromatography is used in carbohydrate research to determine molecular weight distributions of polysaccharides. A variety of detection methods have been used, among them viscometry, lowangle laser light scattering (LALLS), refractive index, ultraviolet/visible absorbance, fluorescence, and precision differential refractometry coupled with ultraviolet detection.This a...