The inhibition of glycolysis by respiration (Pasteur effect) and the inhibition of respiration by glycolysis (Crabtree effect) represent nonhormonal regulatory mechanisms of cellular metabolism. Some of the previous work on these phenomena in intact cells will be reviewed in subsequent papers (1, 2) together with a report on recent experimental work on ascites tumor cells. The difficulty of obt...

Institut Pasteur, Epidemiology and Physiopathology of Oncogenic Viruses Unit, CNRS URA 3015 (N Berthet PhD, Prof A Gessain PhD), and Institut Pasteur, Laboratory for Urgent Responses to Biological Threats (A-M Burguière Pharm, J-C Manuguerra PhD), Paris, France; Institut Pasteur in Bangui, Department of Virology, Bangui, Central African Republic (E Nakouné PhD, B Selekon BSc, M Kazanji PhD); an...

Loredana Puca, Patricia Chastagner, Vannary Meas-Yedid, Alain Israël and Christel Brou* Institut Pasteur and CNRS URA 2582, Signalisation Moléculaire et Activation Cellulaire, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France University Pierre et Marie Curie, Cellule Pasteur UPMC, 25 Rue du Docteur Roux, 75724 Paris Cedex 15, France Institut Pasteur and CNRS URA 2582, Unité d’Analyse d’Image...

to work with non-pathogens may be tempted by the availability of funds to focus on pathogens and submit grant proposals to a biodefence programme. But this too has financial implications, because dangerous organisms can be investigated only within expensive, high containment facilities. Moreover, there is considerably less existing knowledge to build upon in the case of most pathogens than exis...

More than 125 years after its foundation (*), the Pasteur Institute is still one of the world’s largest, best known and most powerful biomedical research institutions. The original motherhouse was founded by Louis Pasteur in 1888 thanks to the funds and facilities generously provided by the Paris municipality and the French state and also to the donations of voluntary contributors from France a...