In the present paper, we studied the influence of different levels of dietary polyunsaturated fatty acids (PUFA) on the immune system and tumor growth in young mice. Female BALB/c mice fed a PUFA-rich diet display an enhanced body growth, proliferative response to mitogens in vitro, and rate of growth of a spontaneous transplantable adenocarcinoma as compared to PUFA-poor diet-fed females. Such...

Mouse fibroblast LM cells have been modified with respect to the content of polyunsaturated fatty acyl (PUFA) chains of the membrane phospholipids. The membranes of the modified cells were enriched in PUFA chains and were more fluid as compared to the normal cells, as judged by fluorescence polarization measurements. The thermosensitivity of the PUFA-substituted cells was enhanced. Thermotolera...

Objective. To determine the relationship between dietary omega-3 fatty acids (n-3 PUFA) and omega-6 fatty acids (n-6 PUFA) with prostate cancer risk from meta-analysis of prospective studies. Design. The literature retrieved from electronic biomedical databases up to June 2011 was critically appraised. General variance-based method was used to pool the effect estimates at 95% confidence interva...

Consumers are increasingly becoming more aware of the relationships between diet and health. The functional–food components of beef and milk fat include ω–3 polyunsaturated fatty acids (PUFA) and conjugated linoleic acid (CLA). Beef typically has high saturated fatty acid content and low PUFA content, but the content of beneficial fatty acids can be increased by dietary manipulation. Dietary li...

Depression may be associated with impaired membrane PUFA composition, especially decreased n-3 PUFA. This assumption has not been tested at the level of brain tissue. Moreover, most studies were confounded by dietary variability. We examined the FA composition of selected brain areas in an animal model of depression, the Flinders Sensitive Line (FSL) rat, and compared the findings with those in...

Abstract The aim of the work was to study the dealyed effect of lipopolysaccharide (LPS) administration on endothelial function of the aorta of rats with genetic hypertension (SHR). Further, the possibility to ameliorate LPS-induced changes by omega-3 fatty acids (PUFA) was tested. Rats received bolus of 1mg/kg LPS i.p.; PUFA were administered in the dose of 30 mg/kg daily for 10 days p.o.. Ten...

The mechanisms by which n-3 polyunsaturated fatty acids (PUFAs) decrease colon tumor formation have not been fully elucidated. Examination of genes upor down-regulated at various stages of tumor development via the monitoring of gene expression relationships will help to determine the biological processes ultimately responsible for the protective effects of n-3 PUFA. Therefore, using a 3 2 2 fa...

BACKGROUND Distiller's dried grains with solubles (DDGS) and soybean meal were used as the substrates for the production of polyunsaturated fatty acids (PUFA) in solid-state fermentation (SSF) by Mortierella alpine. These fermented products were fed to laying hens. PUFA enrichment from chicken breasts was studied. METHODS The maximum productivity of PUFA was achieved under optimized process c...

The brain is a lipid-rich organ containing mostly complex polar phospholipids, sphingolipids, gangliosides and cholesterol. These lipids are involved in the structure and function of cell membranes in the brain. The glycerophospholipids in the brain contain a high proportion of polyunsaturated fatty acids (PUFA) derived from the essential fatty acids, linoleic acid and alpha-linolenic acid. The...

BACKGROUND Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are promoted as cognitive enhancers with consumption recommended in the general population and those with neurocognitive deficits such as attention deficit hyperactivity disorder (ADHD). However, evidence from randomised placebo-controlled trials is inconclusive. AIMS This study aimed to conduct a systematic review and meta-analysis e...