Panaxatriol saponins (PTS), the main components extracted from Panax notoginseng, have been shown to be efficacious in the prevention and treatment of cerebrovascular diseases in China. NF-E2-related factor 2 (Nrf2), a transcription factor regulating antioxidant and cytoprotective responses to oxidative stress, has received particular attention as a molecular target for pharmacological interven...

Methods Our retrospective study included 59 Pts (20 boys, 39 girls), who used B. All Pts had diagnosis of sJIA, established according to the ILAR classification criteria. The clinical characteristic at the time of 1 prescription: mean age of 6.25, range 2.0-17.75 yrs; mean disease duration of 4.5, range 0.3-15.9 yrs; 61% of Pts had active systemic features, 98.3% arthritis. The previous therapy...

BACKGROUND Panaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, the mechanism underlying the effects of PTS remains unclear. This study aimed to determine whether PTS can protect against ischemic brain injury by promoting angiogenesis and to explore the possible mechanism by whi...

The role of the tumor suppressor mothers against decapentaplegic homolog 4 (SMAD4) has not yet been defined in patients (pts) with advanced pancreatic cancer (aPC). This translational research study was designed to evaluate the impact of tumoral SMAD4 loss on clinicopathological parameters and outcome in PC patients receiving palliative chemotherapy. Using immunohistochemistry, we examined SMAD...

BACKGROUND Exposure to prenatal tobacco smoke (PTS) has been associated with a number of health outcomes in the offspring, including some childhood cancers. Lower levels of genomic DNA methylation have also been associated with several types of cancers. We investigated whether PTS was associated with global DNA methylation levels in the offspring. METHODS Our sample was drawn from a birth coh...

Partial transmit sequence (PTS) is an attractive technique for PAPR reduction without distortion, but to obtain preferable PAPR performance it needs many inverse fast Fourier transforms (IFFTs), which results in high computational complexity. In order to reduce the complexity, modified PTS technique, with real and imaginary parts, separately multiplied with phase factors is considered in this p...

Uterine adenosarcomas and breast phyllodes tumors (PTs) are morphologically similar, being composed of stromal projections in a leaf-like fashion lined by epithelial cells. Here, we investigated whether their histologic similarities would be mirrored at the genetic level. The previously reported repertoires of somatic genetic alterations found in 19 adenosarcomas and 22 PTs (six benign, six bor...

OBJECTIVES Repair of thoracic aneurysms (TA) involving the ascending, arch, and descending aorta results in substantial morbidity and mortality. This study evaluates outcomes with a two-stage elephant trunk (ET) technique. METHODS Two hundred and fifteen consecutive patients (pts) underwent total arch replacement using an ET (02/90-09/06). One hundred and thirty-nine pts (65%), group PC (plan...

Title of Dissertation: ROLE OF THE PHOSPHOENOLPYRUVATE: CARBOHYDRATE PHOSPHOTRANSFERASE SYSTEM IN THE VIRULENCE OF THE GROUP A STREPTOCOCCUS Kanika Gera, Doctor of Philosophy, 2014 Directed By: Dr. Kevin S. McIver, Associate Professor Department of Cell Biology and Molecular Genetics Group A Streptococcus (GAS) is a fastidious microorganism that has adapted to a variety of niches in the human b...

INTRODUCTION AND OBJECTIVES Several biomarkers have been used for evaluation and quantification of myocardial injury after effective ablation. We studied possible different thermal stability and usability of the proteins released by cardiac cells injured by different energy sources. METHODS Firstly, we tested in vitro thermal stability of creatinine kinase (CK), myocardial bound creatinine ki...