نتایج جستجو برای: ptk

تعداد نتایج: 1449  

Journal: :Japanese journal of ophthalmology 1999
S Amano T Oshika Y Tazawa T Tsuru

PURPOSE To evaluate long-term follow-up results of excimer laser phototherapeutic keratectomy (PTK) in a Japanese population. METHODS Twenty-six patients (31 eyes) with corneal opacity were treated with excimer laser PTK. Preoperative diagnoses included 16 eyes with band keratopathy, 10 with granular dystrophy, and 5 with corneal scar. Mean postoperative follow-up was 27 months. RESULTS Cor...

Journal: :European journal of ophthalmology 2009
George Kymionis Takeshi Ide Sonia Yoo

PURPOSE To report a patient with severe post-laser in situ keratomileusis (LASIK) epithelial ingrowth and keratolysis treated with flap amputation and phototherapeutic keratectomy (PTK) with adjuvant intraoperative mitomycin C (MMC). METHODS Case report. RESULTS A 55-year-old woman was referred to our department due to severe post-LASIK epithelial ingrowth with corneal melting 2 years after...

2010
Seong-Kyu Im Kwang-Hoon Lee Kyung-Chul Yoon

PURPOSE The objective of this study is to evaluate the therapeutic efficacy of ethylenediaminetetraacetic acid (EDTA) chelation and excimer laser phototherapeutic keratectomy (PTK) combined with amniotic membrane transplantation (AMT) for the treatment of band keratopathy (BK). METHODS Eleven eyes in ten patients with BK received combined PTK (ablation zone of central 7.0-7.5 mm, depth of 50 ...

Journal: :Journal of immunology 2000
M C Bosco R E Curiel A H Zea M G Malabarba J R Ortaldo I Espinoza-Delgado

The activating properties of IL-2 and the structure of the IL-2R on human monocytes are well characterized. However, relatively little is known about the biochemical mechanisms involved in IL-2 signal transduction in these cells. We investigated the role of protein tyrosine kinases (PTKs) in the activation of monocytes by IL-2. Incubation of monocytes with the PTK inhibitor herbimycin A (HA) re...

Journal: :The Journal of Experimental Medicine 1998
Aimin Jiang Andrew Craxton Tomohiro Kurosaki Edward A. Clark

B cell antigen receptor (BCR) cross-linking activates three distinct families of nonreceptor protein tyrosine kinases (PTKs): src-family kinases, Syk, and Btk; these PTKs are responsible for initiating downstream events. BCR cross-linking in the chicken DT40 B cell line also activates three distinct mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase (ERK)2, c-jun N...

Journal: :Developmental biology 2004
Ming Li Nataliya A Babenko Donald S Sakaguchi

In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vitro. Application of the inhibitors to early embryonic retina disrupted the patt...

Journal: :Infection and immunity 2010
Thomas A Russo Nicole R Luke Janet M Beanan Ruth Olson Shauna L Sauberan Ulrike MacDonald L Wayne Schultz Timothy C Umland Anthony A Campagnari

Acinetobacter baumannii is a pathogen of increasing medical importance with a propensity to be multidrug resistant, thereby making treatment challenging. Little is known of virulence traits in A. baumannii. To identify virulence factors and potential drug targets, random transposon (Tn) mutants derived from the A. baumannii strain AB307-0294 were screened to identify genes essential for growth ...

Journal: :The Journal of biological chemistry 1991
K Alexandropoulos C K Joseph R Spangler D A Foster

The protein-tyrosine kinase (PTK) v-Fps induces protein kinase C (PKC)-dependent expression of the transformation-related 9E3 gene in chicken embryo fibroblasts (Spangler, R., Joseph, C., Qureshi, S.A., Berg, K., and Foster, D.A. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 7017-7021). We present evidence here that a GTP-binding protein (G-protein) is a component of this PKC-dependent signaling pat...

Journal: :Environmental Health Perspectives 1997
Y Lim S H Kim K A Kim M W Oh K H Lee

Although asbestos stimulates oxygen radical generation in alveolar macrophages, the exact mechanism is still not clear. The purpose of this study was to compare the ability of three asbestos fibers (amosite, chrysotile, and crocidolite) to generate oxygen radicals in macrophages and examine the mechanism of this action. All asbestos fibers were able to induce chemiluminescence but chrysotile in...

Journal: :Current issues in molecular biology 2006
Irina V Schemarova

The review summarizes for the first time the current concepts of the role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes. Evolutionary concepts are developed about the origin of protein tyrosine kinases (PTK)-signaling.

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