background : immunogenicity of streptokinase (stk), as a thrombolytic drug, have limited its clinical use. elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of stk is worthy. recently, we modified the stk through elimination of 42 amino acids from its’ c-terminal and assessed its bioactivity in vitro . objective : in this study, bi...

In the present study, we identified free amino acid (FAA) contents and chemical composition in four populations of Salmo trutta macrostigma living in Mediterranean region of Turkey. In addition, taste impacts of FAAs were evaluated by taste active values. Moisture, protein, fat and ash content were found in the ranges of 75.49 - 79.59 %, 16.94 - 19.97 %, 1.58 - 3.75 % and, 1.39 - 1.56 %, respec...

Treatment of unresponsive hypoparathyroidism when the oral route administration is not possible: Considering subcutaneous teriparatide Tratamiento con PTH subcutánea en el hipoparatiroidismo posquirúrgico de difícil control cuando la vía oral no está disponible PTH is a polypeptide of 84 amino acids with an active fragment of 34 amino acids in the N-terminal extreme. It is secreted by the parat...

Nutritional value of freshwater mesozooplankton, fatty acid (FA) and amino acid (AA) compositions were determined in the middle of each season for a one-year period from May 2009 to February 2010 in Hanna Dam Lake, Isfahan, Iran. FA and AA composition significantly (P<0.05) varied in relation to the seasonal changes of water quality, phytoplankton and zooplankton community. The content of satur...

Parathyroid hormone (PTH) and PTH-related protein (PTHrP) are two factors that share amino acid sequence homology and act via a common receptor. In tetrapods, PTH is the main endocrine factor acting in bone and kidney to regulate calcium and phosphate. PTHrP is an essential paracrine developmental factor present in many tissues and is involved in the regulation of ossification, mammary gland de...

The role of various parathyroid hormone (PTH) radio-immunoassays in the diagnosis of primary hyperparathyroidism (PHP) is controversial. A series of 204 patients with surgically proven PHP was studied. Serum total calcium, serum ionized calcium, amino (N)-terminal PTH and carboxyl(C)-terminal PTH were assessed in relation to the volume and weight of adenomatous or hyperplastic parathyroid tissu...

we used various screening techniques, clustering, decision tree and generalized rule induction (association) (gri) models and molecular phylogenic relationship to search for patterns of halophi-licy and to find features contribute to halolysin salt stability. we found met was the sole n-terminal amino acid in halolysin proteins, whereas other amino acids found at this position of oth-er proteas...

The function of amino-terminal pro-specific peptides (propeptides), sequences often found on intermediate precursor forms of secreted proteins, is poorly understood. Human preproparathyroid hormone (prepro-PTH), a precursor protein containing such a propeptide, is initially synthesized as a precursor containing a 25-amino acid signal sequence, a 6-amino acid propeptide, and the 84-amino acid ma...