BACKGROUND AND OBJECTIVES Cebranopadol is a novel first-in-class analgesic acting as a nociceptin/orphanin FQ peptide and opioid peptide receptor agonist with central analgesic activity. It is currently in clinical development for the treatment of chronic pain conditions. This trial focuses on the clinical pharmacokinetic (PK) properties of cebranopadol after oral single- and multiple-dose admi...

One of the principal motivations of wide-field and synoptic surveys is the search for and study of transients. By transients I mean those sources which arise from the background, are detected, and then fade away to oblivion. Transients in distant galaxies need to be sufficiently bright so as to be detectable and in almost all cases these transients are catastrophic events, marking the deaths of...

[1] The focus of this study is on the role of precipitation uncertainty in the estimation of soil texture and soil hydraulic properties for application to land-atmosphere modeling systems. This work extends a recent study by Santanello et al. (2007) in which it was shown that soil texture and related physical parameters may be estimated using a combination of multitemporal microwave remote sens...

• Soil shear strength, τ, was measured in intact topsoil at six matric potentials. The preload suction stress (PSS) estimated from water saturation and suction. Normal load, PSS, density, clay organic matter explained >90 % of variation τ. model predicted well τ for two independent data sets. the trend also subsoil Distortion soil stresses during field traffic may be even more damaging to funct...

Abstract Double white dwarf (DWD) binaries are important for studies of common-envelope (CE) evolution, Type Ia supernova progenitors and Galactic sources low-frequency gravitational waves. PTF J0533+0209 is a DWD system with short orbital period P orb ∼ 20 minutes thus so-called LISA verification source. The formation this other DWDs still under debate. In paper, we discuss the possible scenar...

be described adequately by a soil hydraulic model that is a closed-form equation with a certain number of paramParametric pedotransfer functions (PTFs), which predict parameeters, e.g., Brooks and Corey or van Genuchten equation. ters of a model from basic soil properties are useful in deriving continuous functions of soil properties, such as water retention curves. The A parametric approach is...