Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large-scale behaviors of these systems. Here, we investigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can fo...

Many cellular processes are driven by cytoskeletal assemblies. It remains unclear how cytoskeletal filaments and motor proteins organize into cellular scale structures and how molecular properties of cytoskeletal components affect the large scale behaviors of these systems. Here we inves5 tigate the self-organization of stabilized microtubules in Xenopus oocyte extracts and find that they can f...

Cytoplasmic dynein-1 is a minus-end-directed motor protein that transports cargo over long distances and organizes the intracellular microtubule (MT) network. How dynein motor activity is harnessed for these diverse functions remains unknown. Here, we have uncovered a mechanism for how processive dynein-dynactin complexes drive MT-MT sliding, reorganization, and focusing, activities required fo...

As a specific form of physical education, professional-applied training is an independent psycho-pedagogical process, aimed at ensuring specialized on continuous basis, towards preferred professional activity, wishing to be instructive process that completes the individual background professionally useful psychomotor skills and abilities. Continuous improvement motor, mental, moral, volitional ...

BACKGROUND There is evidence that blockade of 5-HT 6 receptors can improve cognitive dysfunction in schizophrenic patients. A number of antagonists of 5-HT6 receptors are in development as cognitive enhancers. One of the agents with relatively strong 5-HT6 activity is dimebon. We tested the hypothesis that this 5-HT6 antagonist administered in the early stage of stabilization after an acute epi...

fundamental motor skills are key components of motor development and are divided into two main sub groups including fine and gross motor skills. the main purpose of the present study was to determine the effect of balance training with swiss ball (btwsb) on gross motor skill of children with attention deficit – hyperactivity disorder. participants of the present study were three 6 to 8 years ol...