Abstract The aim of this study was to estimate the contribution adult attachment style and alexithymia cutaneous body image in patients with psoriasis while controlling for confounding effects disease severity depressive symptoms. Participants were 107 consecutive (60% women) a diagnosis plaque-type psoriasis. Cutaneous dissatisfaction measured Body Image Scale (CBIS) Psoriasis Area Severity In...

Because data on the epidemiology of psoriasis in central and eastern Europe are scarce, a survey was carried out among dermatologists in the Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, and Slovenia. The objective of the survey was to determine disease severity, treatment patterns, proportions of dermatologists considering their patients' current treatments un...

Background: Many efforts are made to find new and more effective treatments for psoriasis. Intralesional 5-Fluorouracil (5-FU) +epinephrine is a cheap option which can be administered with long intervals. The effectiveness of Pulse Dye Laser (PDL) on psoriasis has been already assessed. We decided to evaluate the effectiveness of 5-FU+epinephrine and compare it to betamethasone and PDL.</...

Psoriasis is a common chronic inflammatory skin condition that varies in severity. associated with complex disorders, which incorporate metabolic syndrome, obesity and impaired glucose tolerance. Adipose tissue secretes several hormones cytokines, particular visfatin resistin could be involved the development of psoriasis by acting as pro-inflammatory or immunoregulatory factors. The aim this w...

Background: Psoriasis has been characterized by hyperproliferation accompanied by acanthosis and aberrant differentiation of keratinocytes. Several growth factors and cytokines, are assumed to be important. Recent studies indicate that various cytokines including tumor necrosis factor α ( TNF α ), IL 2R and IL 6 play an essential role in the induction and maintenance of psoriatic lesion. Object...

AIM Psoriasis is a common, chronic, immune-mediated skin disorder that may be complicated by psoriatic arthritis in up to one-third of patients. Psoriasis treatments are increasingly effective, yet more expensive, thus requiring rational decision-making on interventional priorities. The ability to perform cost-utility analyses is hindered by the lack of algorithms that allow the inference of ut...

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokin...

BACKGROUND Psoriasis severity and treatment responsiveness vary by body region, which differentially impacts quality of life (QoL). OBJECTIVE The objective of the study was to examine adalimumab efficacy by body region and regional response and QoL relationship. METHODS Patients (n = 1212) with moderate-to-severe psoriasis were randomized 2:1 to 80 mg at week 0, followed by adalimumab 40 mg...

BACKGROUND & OBJECTIVES Psoriasis is a chronic, recurrent skin disorder, with a poorly understood pathogenesis. Studies at molecular/genetic levels continue to explore various biomolecules as potential markers of the disease. In the present study, we sought to evaluate the possible roles of ferritin and iron in psoriasis. METHODS Patients with psoriasis (n=81) and healthy controls (n=45) were...