Filopodia are actin-rich finger-like cytoplasmic projections extending from the leading edge of cells. Unconventional myosin-X is involved in the protrusion of filopodia. However, the underlying mechanism of myosin-X-induced filopodia formation is obscure. Here, we studied the movements of myosin-X during filopodia protrusion using a total internal reflection microscope to clarify the mechanism...

OBJECTIVE To investigate possible protrusions through stent cells, and the factors affecting protrusions after carotid angioplasty and stenting (CAS). METHODS This ex-vivo clinical study was performed between July 2010 and August 2011 at the Department of Radiology, Ege University School of Medicine, Izmir, Turkey. After approval by the Institutional Board, 15 successive carotid plaques, whic...

Mechanical properties of neutrophils have been recognized as key contributors to stabilizing neutrophil rolling on the endothelium during the inflammatory response. In particular, accumulating evidence suggests that surface protrusion and tether extraction from neutrophils facilitate stable rolling by relieving the disruptive forces on adhesive bonds. Using a customized optical trap setup, we a...

The present study investigated the existence of a relationship between depression and body posture in 40 women, aged between 20 and 30 years, who had normal body mass indices (or were underweight) and absence of neurological, psychiatric, or musculoskeletal disorders. The aim of the present study was to investigate the existence of a relationship between sadness, depression and the posture repr...

AIM To assess if mandibular incisor proclination and protrusion during treatment with the Herbst/multibracket appliance can be prevented through simple screws (MIs) anchorage. MATERIAL AND METHODS After a statistical power analysis, 12 Herbst patients with MIs (100% MIs survival) ligated to the Herbst/multibracket appliance to reinforce anchorage were investigated. A control group matched for...

Proper morphogenesis of neuronal dendritic spines is essential for the formation of functional synaptic networks. However, it is not known how spines are initiated. Here, we identify the inverse-BAR (I-BAR) protein MIM/MTSS1 as a nucleator of dendritic spines. MIM accumulated to future spine initiation sites in a PIP2-dependent manner and deformed the plasma membrane outward into a proto-protru...

Three dogs were presented with lumbosacral hyperesthesia. Computerized tomography scans were performed in all the cases, and magnetic resonance imaging was also performed in cases 1 and 3. There was intervertebral disc (IVD) protrusion causing nerve root compression and epidural gas accumulation in all the three cases. The gas-filled cystic structures in cases 1 and 3 were within the spinal can...

The aims of this study were to compare the maximum range of protrusion determined with a ruler with measurements made using a George Gauge (GG) and to validate the methods of measurement (ruler and GG) of the advancement established by mandibular protruding devices (MPDs), using cephalograms as the gold standard. The study comprised 77 patients (63 males, 14 females, mean age 54 years, range 31...

Cell migration on a two-dimensional flat surface has been extensively studied and is generally characterized by a front-protrusion-rear-contraction process. In a three-dimensional (3D) environment, on the other hand, cells adopt multiple migration strategies depending on the cell type and the properties of the extracellular matrix (ECM). By using computer simulations, we find that these migrati...

Protrusion, the first step of cell migration, is driven by actin polymerization coupled to adhesion at the cell's leading edge. Polymerization and adhesive forces have been estimated, but the net protrusion force has not been measured accurately. We arrest the leading edge of a moving fish keratocyte with a hydrodynamic load generated by a fluid flow from a micropipette. The flow arrests protru...