BACKGROUND Intracranial haemorrhage is a serious and potentially fatal complication of oral anticoagulant therapy. Prothrombin complex concentrates can substantially shorten the time needed to reverse the effects of oral anticoagulants. The aim of this study was to determine the efficacy and safety of a prothrombin complex concentrate for rapid reversal of oral anticoagulant therapy in patients...

Recent advances in physiology Dam (1934; 1935) observed that chicks on synthetic diets developed haemorrhages uncontrollable by vitamins A, C and D. He therefore attributed the bleeding tendency to lack of a specific food factor, vitamin K (coagulation vitamin). Dam and Schonheyder (1934) demonstrated that the delay in coagulation in chicks on diets deficient in vitamin K was not caused by a di...

background: eukaryotic proteins generally have signal peptides, which are not only crucial for their secretion efficiencies but are important for their expression levels. the coagulation factor ix (fix) is a glycoprotein that plays a fundamental role in a blood coagulation pathway. reduced levels or dysfunctional fix are associated with hemophilia b. to improve the hfix secretion efficiency in ...

Staphylocoagulase (SC) is a potent nonproteolytic prothrombin (ProT) activator and the prototype of a newly established zymogen activator and adhesion protein family. The staphylocoagulase fragment containing residues 1-325 (SC-(1-325)) represents a new type of nonproteolytic activator with a unique fold consisting of two three-helix bundle domains. The N-terminal, domain 1 of SC (D1, residues ...

BACKGROUND AND OBJECTIVE Factor V Leiden is the most important risk factor for hereditary thromboembolism, whereas the mutation in the 3'-untranslated region of the prothrombin gene seems to be only a mild risk factor for thrombotic events. On the other hand the factor V mutation (Arg 506) is frequently coinherited with the prothrombin 3'-untranslated region G20210A variant and there is increas...

The bleeding tendency that develops in bile fistula dogs, completely or partially deprived of bile, is due to a prothrombin deficiency of the blood plasma. However, a relatively low prothrombin level may exist in these animals without the occurrence of spontaneous hemorrhage. The prothrombin level may remain within the limits of normal if sufficient bile has been fed. In these cases no disturba...

We have evaluated the contribution of depression of individual procoagulant vitamin K-dependent clotting factors to the ability of warfarin to protect rabbits against tissue factor-induced coagulation. Mean activities of individual procoagulant factors were determined, in assays with rabbit substrates, for a group of rabbits achieving a protective degree of anticoagulation with warfarin. Values...