BACKGROUND Protein tyrosine phosphatase non-receptor type 1 is a therapeutic target for the type 2 diabetes mellitus. According to the International Diabetes Federation 2015 report, one out of 11 adults suffers from diabetes mellitus globally. OBJECTIVE Current anti-diabetic drugs can cause life-threatening side-effects. The present study proposes a pipeline for the development of effective a...

Protein tyrosine phosphatase interacting protein51 (PTPIP51) interacts both in vit ro and in v ivo withPTP1B, a protein tyrosine phosphatase involved in cellularregulation. PTPIP51 is known to be expressed in manydifferent types of tissues. It is involved in cellular processessuch as proliferation, differentiat ion and apoptosis. Never-theless, the exact cellular functio...

Protein tyrosine phosphorylation is a ubiquitous, fundamental biochemical mechanism that regulates essential eukaryotic cellular functions. The level of tyrosine phosphorylation of specific proteins is finely tuned by the dynamic balance between protein tyrosine kinase and protein tyrosine phosphatase activities. Hepatocyte growth factor receptor (also known as Met), a receptor protein tyrosine...

Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. Tyrosine (Tyr) has recently emerged as being important plant receptor kinase (RK)-mediated signaling, particularly during immunity. How Tyr regulates RK function however largely unknown. Notably, the expansion phosphatase and SH2 domain-containing families, wh...

We conducted a study to identify circular RNAs associated with invasive non-functioning pituitary adenomas and chemoresistance, as well construct competitive endogenous RNA network. performed expression profiling of 10 specimens using sequencing identified 37 differentially expressed RNAs, which were validated real-time quantitative polymerase chain reaction. also detected 26 microRNAs 388 mess...