نتایج جستجو برای: protein families

تعداد نتایج: 1343866  

2016
Hugo P. Bastos Lisete Sousa Luka A. Clarke Francisco M. Couto

BACKGROUND Biological sequences, such as proteins, have been provided with annotations that assign functional information. These functional annotations are associations of proteins (or other biological sequences) with descriptors characterizing their biological roles. However, not all proteins are fully (or even at all) annotated. This annotation incompleteness limits our ability to make sound ...

Journal: :General physiology and biophysics 1998
J A Brannigan

Journal: :Current opinion in structural biology 2001
E V Kriventseva M Biswas R Apweiler

Various sequence-motif and sequence-cluster databases have been integrated into a new resource known as InterPro. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments complement each other for grouping protein families and delineating domains. InterPro and new developments in the analysis of both the phylogenetic profiles of...

Journal: :WormBook : the online review of C. elegans biology 2005
Erich M Schwarz

This chapter reviews analytical tools currently in use for protein classification, and gives an overview of the C. elegans proteome. Computational analysis of proteins relies heavily on hidden Markov models of protein families. Proteins can also be classified by predicted secondary or tertiary structures, hydrophobic profiles, compositional biases, or size ranges. Strictly orthologous protein f...

Journal: :Plant physiology 1995
J M Stone J C Walker

Enzymes of the eukaryotic protein kinase superfamily catalyze the reversible transfer of the gamma-phosphate from ATP to amino acid side chains of proteins. Protein kinase function can be counteracted by the action of phosphoprotein phosphatases. Phosphorylation status of a protein can have profound effects on its activity and interaction with other proteins. An estimated 1 to 3% of functional ...

Journal: :Physiological genomics 2002
Ping Liang Bernard Labedan Monica Riley

The well-researched Escherichia coli genome offers the opportunity to explore the value of using protein families within a single organism to enrich functional annotation procedures and to study mechanisms of protein evolution. Having identified multimodular proteins resulting from gene fusion, and treated each module as a separate protein, nonoverlapping sequence-similar families in E. coli co...

2002
Ping Liang Bernard Labedan Monica Riley

Ping Liang, Bernard Labedan, and Monica Riley Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Marine Biological Laboratory, Woods Hole, MA 02543, USA 2 Present address: Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA Institut de Génétique et Microbiologie, CNRS UMR 8621, Bâtiment 409, Université de ParisSud, 91405 Orsay Cedex, France Corre...

Journal: :Science 1997
R L Tatusov E V Koonin D J Lipman

In order to extract the maximum amount of information from the rapidly accumulating genome sequences, all conserved genes need to be classified according to their homologous relationships. Comparison of proteins encoded in seven complete genomes from five major phylogenetic lineages and elucidation of consistent patterns of sequence similarities allowed the delineation of 720 clusters of orthol...

Journal: :Physical biology 2009
S A Wells J E Jimenez-Roldan R A Römer

We present a comparative study in which 'pebble game' rigidity analysis is applied to multiple protein crystal structures, for each of six different protein families. We find that the main-chain rigidity of a protein structure at a given hydrogen bond energy cutoff is quite sensitive to small structural variations, and conclude that the hydrogen bond constraints in rigidity analysis should be c...

Journal: :Nucleic acids research 2003
Daniel H. Haft Jeremy D. Selengut Owen White

TIGRFAMs is a collection of manually curated protein families consisting of hidden Markov models (HMMs), multiple sequence alignments, commentary, Gene Ontology (GO) assignments, literature references and pointers to related TIGRFAMs, Pfam and InterPro models. These models are designed to support both automated and manually curated annotation of genomes. TIGRFAMs contains models of full-length ...

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