This study clearly demonstrates that a multi-dentate metal coordination to the leaving group, along with O-5 and/or a protecting group at O-6, has a strong effect on the stereoselectivity of chemical glycosylation.

the concept of fault, like other social phenomena, is always changing, following the variable justice. the economic, moral, and philosophical consideration, are the most influential factors in the process of change. however, it seems that, apart from exceptional issues of revolutionary changes, the economic and material factors lead the way. in this historical process, the definitions of fault ...

An efficient two-step synthesis of the potential cholinergic neuronal mapping tracer [~~C]methylaminobenzovesamicol (MABV) is described. A tert-butoxycarbonyl protecting group was used to activate the aniline nitrogen of aminobenzovesamicol toward [ "Clmethyl iodide methylation under basic conditions. Following labeling, the protecting group was removed by brief acid treatment and the final pro...

Biologically essential carbohydrate 6-phosphates, especially trehalose 6-phosphate, can be synthesized easily in excellent overall yields in 2 steps involving minimum protecting group manipulations. We can cleave the diphenylphosphate group for further synthetic objectives.

In our search for a more versatile protecting group that would exhibit fast release rates for peptides, we have designed and developed the p-hydroxyphenacyl (pHP) group as a new photoremovable protecting group. We report the application of this protecting group for the dipeptide Ala-Ala (1) and for the nonapeptide bradykinin (2), two representative peptides that demonstrate C-terminus “caging” ...