Abstract Background To investigate the potential benefit of cytoreductive radiotherapy (cRT) in metastatic castration-resistant prostate cancer (mCRPC) patients receiving abiraterone. Methods From February 2014 to 2019, 149 mCRPC treated with abiraterone were identified. Patients cRT before failure (AbiRT group) matched by one-to-two propensity score without (non-AbiRT group). Results The media...

Background: Prostate cancer is the second form of cancer among men worldwide. For early cancer detection, we should identify tumors in initial stages before the physical signs become visible. The present study aims to evaluate the diagnostic value of cell-free DNA (cfDNA), its comparison with prostate-specific antigen (PSA) level in prostate cancer screening and also in patients with localized ...

Background: Prostate cancer is the most common malignancy in men and the second leading cause of death in all countries of the world. The exact mechanism of prostate cancer is not known. On the other hand, early detection of prostate cancer can lead to a complete cure. Several clinical experiments including Digital Rectum Examination (DRE), biochemistry such as Prostate Specific Antigen (PSA), ...

a new series of n-(5-mercapto-1,3,4-thiadiazol-2-yl)-2-phenylacetamide derivatives (3a-3j) were synthesized via an amidation reaction using edc and hobt in acetonitrile solvent at room temperature condition. chemical structures were characterized by 1h nmr, ir and ms spectroscopic methods and related melting points were also determined. the anticancer activity was evaluated using mtt procedure ...

background: we aimed to value the usefulness of free to total prostate-specific antigen and prostate-specific antigen (psa) density for prostate cancer in the patients with psa levels of 4.0 ng/ml or less. methods: a total of 343 subjects with psa levels of 4.0 ng/ml or less were biopsied. all patients were divided into four groups according to the psa levels: 0 to 1.0 ng/ml, 1.1 to 2.0 ng/ml, ...

BACKGROUND With salvage radiation therapy (SRT) in the postprostatectomy setting, the need to deliver sufficient radiation doses to achieve a high probability of tumor control is balanced with the risk of increased toxicity. Intensity-modulated radiation therapy (IMRT) in the postprostatectomy salvage setting is gaining interest as a treatment strategy. OBJECTIVE Compare acute and late toxici...

to investigate and compare the infectious and non-infectious complications of single-dose versus multiple-dose antibiotic therapy for trans-rectal ultrasound (trus)-guided biopsy of the prostate. patients were enrolled in a prospective randomized study that was designed to investigate the effects of single-dose versus multiple-dose antimicrobial prophylaxis regimen mainly on asymptomatic bacter...

Purpose: To estimate and compare normal tissue toxicity and secondary cancer (SC) risks from 3D conformal radiotherapy (3D CRT), arc radiotherapy (ART) and intensity modulated proton therapy (IMPT) for treatment of pediatric medulloblastoma (MB). The purpose was also to investigate the possibility of optimizing radiotherapy treatment with the aim of reducing normal tissue toxicity as well as th...

Purpose: To retrospectively compare dosimetrically three dimensional field-in-field tangents (3D F-in-F), Intensity modulated radiotherapy (IMRT) and volumetric arc therapy (VMAT) left breast irradiation plans. Materials Methods: A total of 30 patients were included in this study. All diagnosed with early–stage malignant neoplasm the prior to treatment. Patients contoured main PTV-Chest wall (P...