Based on the engineering background of providing advance support for working face mining roadways, this paper studies reasonable technology roadway roofs by combining theoretical analysis, numerical simulation, and field tests. geological conditions 1304 Yineng Coal Mine, FLAC3D simulation software was used to compare analyze effects original single hydraulic prop bolt-mesh-cable without prop. ...

Parkinson’s disease (PD) is a progressive neurodegenerative disorder mainly characterized by movement dysfunction. Earlier, it was found that (1R,2R,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-3-ene-1,2-diol (Prottremin) demonstrated antiparkinsonian activity in vivo on different animal models of PD. The paper presents synthesis new Prottremin derivative, (1R,2R,6S)-2(4-(4-isopropylbenzyl)piperazin...

An efficient synthesis of the 1-hydroxy-2-(prop-2'-enyl)9-anthrone is described. Selective nitration of anthraquinone, reduction to the corresponding amine, diazotization and treatment by sulfuric acid solution afforded the 1-hydroxy-9,10-anthraquinone in good yield as the key intermediate. Reaction with allyl bromide/K2CO3 and subsequent selective reduction accompanie...

An early step in generating specific cell types in embryos involves the commitment of multipotent stem cells to specific lineages. The anterior pituitary gland, with its five cell types originating from a common precursor, provides an instructive model to approach the mechanisms that control mammalian organ development and cell differentiation. Using the well-known model of the Ames dwarf mouse...

The non-steroidal allylic and acetylenic alcohols 1-(4'-nitrophenyl)prop-2-en-1-ol (I) and 1-(4'-nitrophenyl)prop-2-yn-1-ol (II) are oxidized by homogeneous 3 alpha-hydroxysteroid dehydrogenase to the corresponding alpha beta-unsaturated ketones 1-(4'-nitrophenyl)prop-2-en-1-one (III) and 1-(4'-nitrophenyl)prop-2-yn-1-one (IV), which then inactivate the enzyme selectively with high affinity; lo...

In an effort to develop new potent antimicrobial and anticancer agents, new pyrrole-based chalcones were designed and synthesized via the base-catalyzed Claisen-Schmidt condensation of 2-acetyl-1-methylpyrrole with 5-(aryl)furfural derivatives. The compounds were evaluated for their in vitro antimicrobial effects on pathogenic bacteria and Candida species using microdilution and ATP luminescenc...

Cellulose nanocrystal (CNC) has potential to be used as a reinforcement in polymeric nanocomposites because of their inherent biodegradability, universal accessibility, and superior mechanical prop...