We have developed a model of gamma-aminobutyric acid (GABA)ergic synaptic transmission mediated by GABAA and GABAB receptors, including cooperativity in the guanine nucleotide binding protein (G protein) cascade mediating the activation of K+ channels by GABAB receptors. If the binding of several G proteins is needed to activate the K+ channels, then only a prolonged activation of GABAB recepto...

Today, neurodegenerative diseases are affecting more and individuals. A typical therapeutic target to treat the progression of symptoms related these is proinflammatory microglia. Diapocynin, dimeric version apocynin, often drug choice. However, suitable carriers for its controlled delivery currently lacking in clinics. In fact, high hydrophilicity hampers development a formulation enabling sus...