Exercise assessment and aerobic exercise training for postconcussion syndrome (PCS) may reduce concussion-related physiological dysfunction and symptoms by restoring autonomic balance and improving cerebral blood flow autoregulation. In a descriptive pilot study of 91 patients referred to a university clinic for treatment of PCS, a subset of 63 patients were contacted by telephone for assessmen...

OBJECTIVES/HYPOTHESIS Aging results in progressive changes in deglutitive functions, which may be due in part to alterations in muscle morphology and physiology. Mastication is a critical component of bolus formation and swallowing, but aging effects on masticatory function have not been well studied. STUDY DESIGN The purpose of this study was to 1) quantify the effects of aging on masticatio...

BACKGROUND Although exercise capacity is an important outcome measure in patients with COPD, its longitudinal course has not been analyzed in comparison to the change in pulmonary function. PURPOSES To examine how exercise capacity would deteriorate over time in patients with COPD, and what factors would contribute to it. METHODS A total of 137 male outpatients with moderate-to-very-severe ...

Regular exercise may improve systemic markers of chronic inflammation, but direct evidence and dose-response information is lacking. The objective of this study was to examine the effect and time course of changes in markers of chronic inflammation in response to progressive exercise training (and subsequent detraining). Forty-one sedentary men 45-64 yr of age completed either a progressive 24-...

BACKGROUND Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive disease. For patients with operable CTEPH, there is a clear recommendation for surgical removal of persistent thrombi by pulmonary endarterectomy (PEA). However, without the presence of PH, therapeutic management of chronic thromboembolic disease (CTED) is challenging - especially in highly trained subjects exceed...

Primary pulmonary hypertension (PPH) is a rare and progressive fatal disease. PPH is a diagnosis of exclusion, and median survival from the time of diagnosis is 2.8 years, if without treatment. Current options for treatment include oxygen, anticoagulation, diuretics, digoxin, calcium channel blockers, prostacyclin, and inhaled nitric oxide. However, endothelin-1 receptor antagonist (ERA) is les...

Aims and objectives: The purpose of this study was to evaluate the effect of Progressive Muscular Relaxation Exercise program on elderly patients in quality of life, functional capacity and the objectives are to identify the level of stress. To test the effect of stress management among elderly persons in the rehabilitation setup. Methodology: Inclusion criteria: geriatric patient, Age group 60...

Indirect measures of cardiac vagal activity are strongly associated with exercise capacity, yet a causal relationship has not been established. Here we show that in rats, genetic silencing of the largest population of brainstem vagal preganglionic neurons residing in the brainstem's dorsal vagal motor nucleus dramatically impairs exercise capacity, while optogenetic recruitment of the same neur...

Despite improvements in disease targeted therapies, pulmonary arterial hypertension (PAH) is a progressive disease and PAH patients remain symptomatic [1]. Exercise intolerance is one of the main symptoms, which limit PAH patients in their daily life activities. Reduced exercise capacity is generally attributed to right ventricular dysfunction [1]. However, as with other cardiac and pulmonary d...

Despite improvements in disease targeted therapies, pulmonary arterial hypertension (PAH) is a progressive disease and PAH patients remain symptomatic [1]. Exercise intolerance is one of the main symptoms, which limit PAH patients in their daily life activities. Reduced exercise capacity is generally attributed to right ventricular dysfunction [1]. However, as with other cardiac and pulmonary d...