نتایج جستجو برای: programmed cell death 1 receptor

تعداد نتایج: 4393069  

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2016
Fei Wang Xin Huang Chun-Shiang Chung Yaping Chen Noelle A Hutchins Alfred Ayala

Recent studies suggest that coinhibitory receptors appear to be important in contributing sepsis-induced immunosuppression. Our laboratory reported that mice deficient in programmed cell death receptor (PD)-1 have increased bacterial clearance and improved survival in experimental sepsis induced by cecal ligation and puncture (CLP). In response to infection, the liver clears the blood of bacter...

Journal: :Development 1996
Y Yokouchi J Sakiyama T Kameda H Iba A Suzuki N Ueno A Kuroiwa

During limb development, the mesenchymal cells in restricted areas of limb bud, anterior necrotic zone, posterior necrotic zone, opaque zone and interdigital necrotic zones, are eliminated by programmed cell death. The transcripts of bone morphogenetic protein (Bmp)-2 and -4 were first detected in the areas where cell death was observed, then showed overlapping expression with the programmed ce...

2017
Shuai Wang Cailin Lei Jiulin Wang Jian Ma Sha Tang Chunlian Wang Kaijun Zhao Peng Tian Huan Zhang Changyan Qi Zhijun Cheng Xin Zhang Xiuping Guo Linglong Liu Chuanyin Wu Jianmin Wan

Lesion-mimic mutants are useful to dissect programmed cell death and defense-related pathways in plants. Here we identified a new rice lesion-mimic mutant, spotted leaf 33 (spl33) and cloned the causal gene by a map-based cloning strategy. SPL33 encodes a eukaryotic translation elongation factor 1 alpha (eEF1A)-like protein consisting of a non-functional zinc finger domain and three functional ...

Journal: :Molecular cancer therapeutics 2009
Hongbo Hu Yubo Chai Lei Wang Jinhui Zhang Hyo Jeong Lee Sung-Hoon Kim Junxuan Lü

Penta-1,2,3,4,6-O-galloyl-beta-d-glucose (PGG) suppresses the in vivo growth of human DU145 and PC-3 prostate cancer xenografts in nude mice, suggesting potential utility as a prostate cancer chemotherapeutic or chemopreventive agent. Our earlier work implicates caspase-mediated apoptosis in DU145 and LNCaP prostate cancer cells as one mechanism for the anticancer activity. We show here that, i...

2013
Shidrokh Ardestani Desirae L Deskins Pampee P Young

BACKGROUND Programmed necrosis is a form of caspase-independent cell death whose molecular regulation is poorly understood. While tumor necrosis factor-alpha (TNF-α) has been identified as an activator of programmed necrosis, the specific context under which this can happen is unclear. Recently we reported that TNF-α can be expressed by human tumor cells as both a membrane tethered (mTNF-α) and...

2005
NORA MOHAMAD ALICIA GUTIÉRREZ MARIEL NÚÑEZ CLAUDIA COCCA GABRIELA MARTÍN GRACIELA CRICCO VANINA MEDINA ELENA RIVERA

Apoptosis or programmed cell death (PCD) is a physiological process characteristic of pluricellular organisms leading to self-destruction of the cell. It is therefore involved in development, homeostasis and host defense. However, a significant difference has been shown between mammalian cell apoptosis and non-mammalian cell apoptosis: mitochondria are implicated only in the former. Execution o...

During programmed cell death (PCD) apoptosis is controlled by many factors such as proteases. With no specific protease (s) known during PCD in the developing nervous system so far, we sought to determine if any specific protease (s) is involved in this process and therefore used different protease inhibitors during PCD (from embryonic day 6 to 10) in chick embryos. Among the inhibitors commerc...

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