We have demonstrated that treating diet-induced obese (DIO) mice with the vasopeptidase inhibitor ilepatril improved neural function. Vasopeptidase inhibitors block angiotensin-converting enzyme (ACE) and neutral endopeptidase (NEP) activity. We propose that increased activity of ACE and NEP contributes to pathophysiology of DIO. To address this issue C57Bl/6J mice or mice deficient in NEP were...

Some animals and humans fed a high-energy diet (HED) are diet-resistant (DR), remaining as lean as individuals who were naïve to HED. Other individuals become obese during HED exposure and subsequently defend the obese weight (Diet-Induced Obesity- Defenders, DIO-D) even when subsequently maintained on a low-energy diet. We hypothesized that the body weight setpoint of the DIO-D phenotype resid...

Nel pensiero di Giovanni Scoto Eriugena si può ritrovare un rapporto analogico sussistente tra Dio e la natura umana. Ultimo dei grandi neoplatonici, egli propone sistema filosofico caratterizzato da movimento universale distinto in tre momenti: creazione, lo sviluppo il ritorno. Essi sono identificati rispettivamente al pensiero, alla parola comprensione; tutti mostrano l’analogia creatore sua...

Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight ...

Outbred Sprague-Dawley rats selectively bred for their propensity to develop diet-induced obesity (DIO) become heavier on low-fat diet than those bred to be diet resistant (DR) beginning at approximately 5 wk of age. Here we assessed the development of metabolic and neural functions for insights into the origins of their greater weight gain. From week 5 to week 10, chow-fed DIO rats gained 15% ...

Questo numero di Ri-Vista nasce nell’Aprile del 2020, in pieno lockdown, con l’esigenza raccogliere alcune delle riflessioni espresse durante il periodo della pandemia prodotta dal COVID-19, nel dibattito sulla qualità dei luoghi che abitiamo, su come questi dovrebbero essere e gli esseri umani abitare pianeta. Un tentativo compilare una sorta diario bordo, o se vogliamo serie appunti, utili a ...