Formation of productive transcription complexes after promoter escape by RNA polymerase II is a major event in eukaryotic gene regulation. Both negative and positive factors control this step. The principal negative elongation factor (NELF) contains four polypeptides and requires for activity the two-polypeptide 5,6-dichloro-1-beta-D-ribobenzimidazole-sensitivity inducing factor (DSIF). DSIF/NE...

Cytosine methylation in CpG dinucleotides is an epigenetic DNA modification dynamically established and maintained by DNA methyltransferases and demethylases. Molecular mechanisms of active DNA demethylation began to surface only recently with the discovery of the 5-methylcytosine (5mC)-directed hydroxylase and base excision activities of ten-eleven translocation (TET) proteins and thymine DNA ...

A formal procedure for managing maintenance activities opens a window of opportunity for the IS manager to consider systems as candidates for reverse engineering, reengineering, and restructuring. This article outlines a software maintenance methodology. It discusses development techniques (e.g., the use of CASE tools and standard data definitions) that help to ensure software maintainability a...

Profiting from spillovers is one of the key reasons behind technological collaboration agreements, agglommeration and even social stratification. Previous research has tended to ignore the costs of activities to internalize the externalities. We propose and solve a simple model for the tradeoff between costly socialization and direct productive effort. Our model can explain phenomena like the r...

The economic development of any region, state or country, depends not only on its natural re‐ sources and productive activities, but also on the infrastructure that account for the exploita‐ tion, processing and marketing of goods. Irrigation systems, roads, bridges, airports, maritime, land and air transport, school buildings, offices and housing, industrial installations are affect‐ ed by cor...

There are many examples of assistive devices for people with manipulative and locomotive disabilities. These devices enable disabled people perform many activities of daily living thus improving their quality of life. Disabled people are increasingly able to lead an independent life and play a more productive role in society. In the case of disabled children, such assistive devices have been sh...

The purpose of money waqf education activities (productive) through community service programs in the East Watukebo Village, Ambulu Jember District was carried out as an effort to provide understanding local about productive, professional, and modern management models. This activity with Muhammadiyah Youth Branch Banyuwangi Java. implementation method for this is lectures direct conducted at An...

This paper argues for analyzing the systematic invisibility of persons living with disabilities by temporalizing their oppression within a framework of “productive time,” which I posit as a normative sense of time by which cultural products and practices appear within capitalist economies. I argue that productive time is employed in cultural evaluations of actions that render persons with disab...