The major glucose transporter of the parasitic protozoan Leishmania enriettii exists in two isoforms, one of which (iso-1) localizes to the flagellar membrane, while the other (iso-2) localizes to the plasma membrane of the cell body, the pellicular membrane. These two isoforms differ only in their cytosolic NH2-terminal domains. Using immunoblots and immunofluorescence microscopy of detergent-...

BACKGROUND-Catecholamine-induced apoptosis is mediated by activation of the beta-adrenergic signaling pathway. We tested the hypothesis that beta(1)- and beta(2)-adrenergic receptor (AR) subtypes differentially affect apoptosis in adult rat ventricular myocytes in vitro. METHODS AND RESULTS-Myocytes were first exposed to norepinephrine (NE) alone (10 mcmol/L) or NE+atenolol (AT) (10 mcmol/L) fo...

AIMS The beneficial effects of 4'-O-methylated flavonoids on induction of melanogenesis are well established. Here, we report the effect of isosakuranetin (Iso) on melanogenesis in B16BL6 melanoma cells and an analysis of the signaling pathways involved in this activity. METHODS B16BL6 melanoma cells were treated with several concentrations of Iso and melanin content was measured. Activation ...

Entropy generation of double diffusive natural convection in a three dimensional differentially heated enclosure has been performed numerically. Vertical walls of enclosure are heated differentially and remaining walls are adiabatic. The obtained results were presented via iso-concentration, iso-temperatures, velocity vector projection, particle trajectories, velocity profiles, iso-entropy, loc...

We present a technique for extracting structural features from cursive Arabic script. After preprocessing, the skeleton of the binary word image is decomposed into a number of segments in a certain order. Each segment is transformed into a feature vector. The target features are the curvature of the segment, its length relative to other segment lengths of the same word, the position of the segm...