Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease with exocrine gland dysfunction and multi-organ involvement. Recent progress in understanding the pathogenesis of pSS offers an opportunity to find new biomarkers for the diagnosis and assessment of disease activity. Screening noninvasive biomarkers from the saliva and tears has significant potential. The need for specific and se...

OBJECTIVE To evaluate the efficacy of the administration of zidovudine (AZT), an antiretroviral drug, in patients with primary Sjögren's syndrome (SS). METHODS Seven female patients (age 57 +/- 8.6 yr) with primary SS were enrolled in an open, uncontrolled trial of AZT (250 mg b.i.d.) for the treatment of primary SS. The efficacy variables were oral and ocular dryness symptoms, fatigue, tende...

1 Casas J A, Subauste C P, Alarc6n G S. A new promising treatment in systemic sclerosis: 5-fluorouracil. Ann Rheum Dis 1987; 46: 763-7. 2 Calabresi P, Parks R E Jr. Chemotherapy of neoplastic diseases. In: Gilman A G, Goodman L S, Rall T W, Murad F, eds. Goodman and Gilman's the pharmacological basis of therapeutics. 7th ed. New York: Macmillan, 1985: 1240-306. 3 Physicians' Desk Reference (PDR...

primary growth hormone insensitivity syndrome (ghis) is a rare entity which can be due to defects in growth hormone (gh) receptor that is called type 1 laron syndrome (t1ls) or post receptor defects (type 2 laron syndrome ). the aim of study was determining the clinical and hormonal milieu of the patients with primary ghis and their response to igf-i (insulin like growth factor-i) generation te...

OBJECTIVE To assess fatigue in relation to depression, blood pressure, and plasma catecholamines in patients with primary Sjögren's syndrome (SS), in comparison with healthy controls and patients with rheumatoid arthritis. METHODS For the assessment of fatigue the Multidimensional Fatigue Inventory (MFI) was used, a 20 item questionnaire, covering the following dimensions: general fatigue, ph...

Considering the great advances regarding the diagnosis and treatment of peritonitis and with respect to the prevalence of patients with primary peritonitis referred to hospitals affiliated to Shiraz university of Medical sciences, this study was performed to evaluate the predisposing and prognostic factors of this condition in children during the years 1982-1992 The descriptive protocol of thi...

Background and Aim: Steroid-resistant nephrotic syndrome (SRNS) accounts for 10%-20% of all cases of idiopathic nephrotic syndrome. These patients are at risk of developing end-stage renal disease. The aim of this study was to determine the demographic characteristics, renal biopsy findings, response to immunosuppressive treatment, and prognosis in pediatric patients with SRNS.Materials and Met...

Objective: The present study was carried out to study the relationship between sensation seeking and social skills in two groups of school age patients Down-Syndrome (DS) and Autism Disorder (DS).  Methods: This is a descriptive-analytic and correlation study in which all participants were of primary school age (10 to 13 years) with Down-Syndrome and Autism Disorder of autism spectrum disord...