iii Abstract Multiple sclerosis (MS) has long been characterized as an inflammatory disease of the central nervous system (CNS); however, recent research has suggested that neurodegenerative processes such as oxidative stress may be the primary force driving disease progression and associated neuropsychological impairment in this population. Recent work by our research group identified GSH, an ...

Introduction: An impaired sense of smell has a remarkable impact on the quality of life. It is seen in a variety of neurodegenerative diseases such as Parkinson disease. In this study, we assessed the olfactory function in patients with Multiple Sclerosis (MS) by Sniff Magnitude Test (SMT).  Methods: A cross-sectional study was conducted on 48 patients with MS. A questionnaire, including demog...

OBJECTIVES To investigate whether axonal damage in primary progressive (PP) multiple sclerosis (MS), as measured by proton magnetic resonance spectroscopy (HMRS) imaging and brain atrophy, is a function of T2 weighted brain lesion volume. METHODS 34 PP MS patients were divided into two categories: low (<3 cm(3), n = 18) or high (>or=3 cm(3), n = 16) T2 lesion load (LL). An Index of Brain Atro...

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS) with inflammatory demyelinating lesions and neuronal loss that is clinically characterised by unpredictable clinical relapses, remissions and progression of disability over time. Damage occurs to the myelin sheath that surrounds and protects nerve cells; this slows down or blocks messages between the brain...

BACKGROUND AND OBJECTIVES The purpose of this systematic review was to evaluate the safety and efficacy of autologous hematopoietic cell transplantation in patients with progressive multiple sclerosis (MS) refractory to conventional medical treatment. METHODS Eight case series met our a priori inclusion criteria for the primary outcome of progression-free survival. Individual study quality wa...

Background: Interleukin (IL)-17/IL-23 axis performs a prominent role in the pathogenesis of several autoimmune disorders. This study aimed to investigate the concentrations of IL-17 in patients with multiple sclerosis (MS) and its relationship with gender, medication, disease forms and single nucleotide polymorphisms (SNP) in IL-23R gene, including rs11209026 and rs1004819. Methods: The blood s...

BACKGROUND African American (AA) individuals are thought to develop multiple sclerosis (MS) less frequently than Caucasian American (CA) individuals. OBJECTIVE To compare the clinical characteristics of AA and CA patients with MS. METHODS The clinical features of MS were compared in a large retrospective cohort of AA (n = 375) and CA (n = 427) subjects. RESULTS The proportion of women to ...