Primary cutaneous lymphomas (CLs) constitute a spectrum of diseases characterized by a clonal accumulation of lymphocytes in the skin. Most CLs display a T(h)2 cytokine profile, including expression of interleukin-10 (IL-10). Because the up-regulation of HLA-G, a nonclassical class Ib molecule inducible by IL-10, might account for the immunescape of the malignant clone, HLA-G and IL-10 expressi...

British Journal of DermatologyVolume 184, Issue 6 p. e206-e206 Plain Language SummaryFree Access Recent changes in the numbers and types lymphomas affecting skin First published: 06 June 2021 https://doi.org/10.1111/bjd.20110AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text full-text accessPlease review our Terms Conditions Use c...

BACKGROUND Epstein-Barr virus (EBV) has been demonstrated in angiocentric immunoproliferative lesions, suggesting that it could be a causative factor. We investigated for the presence of EBV in 12 primary and 2 secondary cutaneous angiocentric lymphomas (CALs). OBSERVATIONS In the 2 secondary CALs, strong reactivity for EBV RNAs and latent membrane protein 1 were detected on paraffin-embedded...

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Primary cutaneous CD4+ smallto medium-sized pleomorphic T-cell lymphoma is included as a provisional entity in the group of primary cutaneous peripheral T-cell lymphomas, both in the latest WHO classification of tumors of hematopoietic and lymphoid tissues and in the WHO-EORTC classification for cutaneous lymphomas. This lymphoma is defined by a predominance of CD4+ smallto mediumsized pleomorp...

diffuse large b cell lymphoma is the most common type of non-hodgkin's lymphoma, representing nearly one-third of all cases. any organ can be involved, making a diagnostic biopsy imperative. when the lungs are the involved organs, it is called primary pulmonary lymphoma (ppl). hereby, we present a case of primary pulmonary lymphoma (ppl) that demonstrated a single large mass on chest ct and had...

In the new World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification of cutaneous lymphomas, large B-cell lymphomas (LBCLs) are divided into 3 groups: LBCL, leg-type (LBCLLT); follicle center lymphoma, diffuse type (FCLDT); and LBCL, others (LBCLO). We studied a large number of primary cutaneous LBCLs to test the validity of the classificati...

Primary cutaneous T-cell lymphomas (CTCLs) are Non-Hodgkin lymphomas where skin may be the only involved organ for a long time. The erythrodermic form of CTCL, including Sezary syndrome, with increased IgE concentration, eosinophilia and intense pruritus, may suggest atopic dermatitis, in the lack of evidence for diagnosis of T-cell lymphoproliferative disorder. After vigorous research, two pat...

Cutaneous T-cell lymphomas are relatively rare lymphomas and the most common form is mycosis fungoides. Its rare leukemic variant is Sezary syndrome. Advanced-stage disease is typically treated with bexarotene (a retinoid), IFN-α or conventional chemotherapeutic agents, but relapses are inevitable. Histone deacetylase inhibitors that modify the epigenome are an attractive addition to the armame...