the renin-angiotensin-aldosterone system (raas) plays pivotal roles in the pathogenesis of chronic kidney disease (ckd) progression and its increased complications such as hypertension (ht) and cardiovascular diseases (cvd). previous studies suggested that aliskiren a direct renin inhibitor, blocks raas and may be effective for the management of ckd and its complications. this review focuses on...

There is a high mortality in patients with diabetes and severe pressure ulcers. For example, chronic pressure sores of the heels often lead to limb loss in diabetic patients. A major factor underlying this is reduced neovascularization caused by impaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1α). In diabetes, HIF-1α function is compromised by a high glucose-...

Background: Skin lesions and blistering in the overdose patient, most notably associated with barbiturate overdoses, are commonly referred to as coma blisters, ‘barb blisters’, or ‘barb burns’. We present a patient who was noted to have skin lesions including bullae and blistering following a prolonged coma after quetiapine overdose. Case report: A 27 year old male presented to our institution ...

Surface micro-structuring of silica glass plates was performed by using laser-induced backside wet etching (LIBWE) upon irradiation with a single-mode laser beam from a diode-pumped solidstate UV laser at 266 nm. We have succeeded in a well-defined micro-pattern formation without debris and microcrack formations around the etched area on the basis of galvanometer-based point scanning system wit...

b a c k ground: csf is a clear liquid that its mechanical properties are to a large extent similar to water properties. regarding the lack of a numerical index for diagnosis of diseases resulting from increased csf pressure such as hydrocephalus, evaluation of hydrodynamic conditions of csf in cerebral ventricular system is of great importance. methods: at first, the diagram of velocity in sylv...

OBJECTIVE Preservation of biological materials at subzero Centigrade temperatures, cryopreservation, is important for the field of tissue engineering and organ transplantation. Our group is studying the use of isochoric (constant volume) systems of aqueous solution for cryopreservation. Previous studies measured the pressure-temperature relations in aqueous isochoric systems in the temperature ...

The main purpose of this study is the survey of the atmospheric low pressure effects at sea level oscillations in the Qeshm Channel. For this purpose, the curves of the pressure on the Persian Gulf and Oman Sea, during the passing of the atmospheric low pressure system, are extracted across the region. During the time of occurrence of these events, sea level oscillations in the coastal areas of...

In this research study, one of the most crucial automotive engineering problems is intended to be solved. The necessity of tire pressure monitoring system is beyond doubt. Such systems are now provided relying on expensive sensors. In this study an indirect tire pressure monitoring system is proposed, utilizing identification techniques, which will reduce the cost of monitoring considerably in ...

compared to conventional chlorination methods which apply chlorine at water treatment plant, booster chlorination has almost solved the problems of high dosages of chlorine residuals near water sources and lack of chlorine residuals in the remote points of a water distribution system (wds). however, control of trihalomethane (thm) formation as a potentially carcinogenic disinfection by-product ...

this paper assumes the cell formation problem as a distributed decision network. it proposes an approach based on application and extension of information theory concepts, in order to analyze informational complexity in an agent- based system, due to interdependence between agents. based on this approach, new quantitative concepts and definitions are proposed in order to measure the amount of t...